A system of surgery . be done, with permission for the surgeon to act ineach case as he thinks best for the patient. If there be any reason-able doubt as to its innocent nature, amputation would, of course, bethe safest course to pursue. 914 DISEASES OF BONES. Sarcoma.—A primary malignant tumour of bone is alwaysone of the varieties of sarcoma, and must necessarily requireamputation or very serious mutilation of the part involved. (Seepage 466.) As regards the structure, little need be added to what has beensaid elsewhere (page 466), except that a large proportion of sarcomataof bone are attri


A system of surgery . be done, with permission for the surgeon to act ineach case as he thinks best for the patient. If there be any reason-able doubt as to its innocent nature, amputation would, of course, bethe safest course to pursue. 914 DISEASES OF BONES. Sarcoma.—A primary malignant tumour of bone is alwaysone of the varieties of sarcoma, and must necessarily requireamputation or very serious mutilation of the part involved. (Seepage 466.) As regards the structure, little need be added to what has beensaid elsewhere (page 466), except that a large proportion of sarcomataof bone are attributed by the patients to some definite injury. The most important distinction has to be drawn at the very out-set between the central and peripheral sarcomata. Central and peripheral sarcomata.—The former start, as the name indicates, from the medullary tissue of the bone, and may be called endosteal. The latter arise, as a rule, in the osteogenetic layer on the surface of bone, and are generally described as sub-. of is another and rarer varietysarcomata, usually designated asThese arise in the tissue immedi-ately outside the periosteum, and only se-condarily invade bone. But, inasmuch as thetreatment is almost the same as for the sub-periosteal sarcomata, it is desirable to mentionthem in reference to this subject. Pathological anatomy.—Both centraland peripheral sarcomata may be round-celled,spindle-celled, or a combination of both. Inthe central alone, if we except an epulis, is atrue myeloid sarcoma ever found. Secondary changes may ensue in them all,the periosteal having an especial tendency tochondrify, ossify, or calcify, whilst the centralare more liable to degenerative softening, andmay become cystic, fatty, or myxomatous. Thecentral are also often exceedingly vascular: acondition which may at one time lead to haemorrhages in its sub-stance, and in another to distinct pulsation. With regard to the coarse anatomy of these sar


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