Manual of pathology : including bacteriology, the technic of postmortems, and methods of pathologic research . hyperplastic neuroglia; indeed, it can not be said that thereis any sharp line of distinction between the two conditions—the twobearing exactlv the same relation to each other that newly formedfibrous tissue in organs bears to the fibromata. The process, which is a • Trcvelyan, Lancet, Nov. 7, 1903, p. 1276. Barbacci, Centralbl. f. allp. Path. u. path. 1902. p. 833. » Shover Jour, of Path, and Bact, March, 1902. Bielschowsky. NeurolOK-CentralbL.*Aug. 16. 1903. Strauhuber. ZieKl


Manual of pathology : including bacteriology, the technic of postmortems, and methods of pathologic research . hyperplastic neuroglia; indeed, it can not be said that thereis any sharp line of distinction between the two conditions—the twobearing exactlv the same relation to each other that newly formedfibrous tissue in organs bears to the fibromata. The process, which is a • Trcvelyan, Lancet, Nov. 7, 1903, p. 1276. Barbacci, Centralbl. f. allp. Path. u. path. 1902. p. 833. » Shover Jour, of Path, and Bact, March, 1902. Bielschowsky. NeurolOK-CentralbL.*Aug. 16. 1903. Strauhuber. ZieKlers Beitr, 1003. B«l. 33. p. Xeurolog. Centralbl. 1904. Bd. 23. No- 3. Spiller, Amer. Jour, ofMed Sci Jan., 1903. Bramwell, Review of Neurol, and Ps>-ch., Jan., Lubarsch and Ostertags <lcr allg. Path. u. path. Anat , Neun-ter lahrg Abt. I, 1903. p. 67. Tredgold, Review of Neurol, and Sluller. Die Multiple Sklcrose d. Gehims u. Rue ken marks, Jena. and Gordon, Amer. Jour, of Med. Sci. Feb. 1905. p. 253. 874 SPECIAL Fig. 411.—Disseminated Sclerosis.—{Gordon.)Areas of sclerosis in the pyramids and nuclei of the medullasclerotic areas are unstained. The very chronic one, sometimes follows such diseases as influenza, malarialand typhoid fevers, but there is no conclusive evidence that theyare the cause; the same is true of syphihs and trauma. The scleroticareas vary much in size, some being only microscopic and othersinvolving an entire lobe of the brain; the nodules may be scanty or numerous, often thelatter, and are irregu-larly distributed in bothbrain and spinal cord;they show no tendencyto follow tracts. Inthe white substance theareas of sclerosis, whensufficiently large,may bedetected by their pinkishcolor, and by being con-siderably harder thanthe neighboring normalbrain tissue; in the graysubstance they are sonearly the same color asthe normal tissue that itis very difficult to d


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