. Adventures in radioisotope research;. Radioactive tracers; Radiobiology. RADIOACTIVE IXDICATORS IN BIOCHEMISTRY 985 inorganic P the specific activity of which corresponds to the mean value of the inorganic P during that time intervaL This mean value, which can be experimentally determined, is denoted by f{^). The contribution of active deoxyribonucleic acid of red corpuscles formed during the first day of the experiment to the total activity of erythrocyte deoxyribo- nucleic acid measured after the lapse of 1 day is f{^) {0 ^), where 0 is a function of the time taken by the transition of the
. Adventures in radioisotope research;. Radioactive tracers; Radiobiology. RADIOACTIVE IXDICATORS IN BIOCHEMISTRY 985 inorganic P the specific activity of which corresponds to the mean value of the inorganic P during that time intervaL This mean value, which can be experimentally determined, is denoted by f{^). The contribution of active deoxyribonucleic acid of red corpuscles formed during the first day of the experiment to the total activity of erythrocyte deoxyribo- nucleic acid measured after the lapse of 1 day is f{^) {0 ^), where 0 is a function of the time taken by the transition of the red corpuscles from the marrow into the circulation, and also of the duration of the life- cycle of the erythrocytes. Actually, we compare, not the deoxyribonucleic acid activities of the total erythrocyte content of the circulation, but the specific activities of deoxyribonucleic acid P fractions. The second day, the corpuscle deoxyribonucleic acid is formed liom inorganic P having a much lower specific activity than the first day. 16 20 24 Time, days. Fig. 6. — Percentage of hen red corpuscles, formed during the first day of the experiment, present in blood stream at the time indi- cated on the a;-axis (Ottesen). the mean value of which is now /(l^). The contribution of active deoxy- ribonucleic acid formed during the second day to the total deoxyril)o- nucleic acid activity measured on the second claj'^ is now /(l^) (0^). The share of the active deoxyribonucleic acid formed in the course of the second day in the total activity of deoxyribonucleic acid of the red corpuscles is somewhat different from the corresponding value during the first day and amounts to /(}) (0^). In a similar way the contribution of the active deoxyribonucleic acid formed during the third day to the total deoxyribonucleic acid activity can be calculated and also the share of the deoxyribonucleic acid formed in the course of the first and second day in the total activity measured on the third day of
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