. A text-book of practical therapeutics, with especial reference to the application of remedial measures to disease and their employment upon a rational basis . id is removed so rapidly that the drug has beencalled the vegetable trocar. Physiological studies show that the action of the drug on the heartis similar to that of digitalis, as it slows the pulse and raises blood-pressure, APOMORPHINE. 97 APOMORPHINE. Apomorphine is an artificial alkaloid obtained by the action of hydro-chloric acid upon morphine in a sealed tube to which is applied a highheat. It is a whitish or gray powder, made up
. A text-book of practical therapeutics, with especial reference to the application of remedial measures to disease and their employment upon a rational basis . id is removed so rapidly that the drug has beencalled the vegetable trocar. Physiological studies show that the action of the drug on the heartis similar to that of digitalis, as it slows the pulse and raises blood-pressure, APOMORPHINE. 97 APOMORPHINE. Apomorphine is an artificial alkaloid obtained by the action of hydro-chloric acid upon morphine in a sealed tube to which is applied a highheat. It is a whitish or gray powder, made up of minute crystals,which rapidly undergo decomposition when exposed to the air. Thedrug should be kept in dark bottles well stoppered. A very importantpoint to remember is that solutions rapidly decompose, and, if employed,may produce poisonous symptoms. The drug ought to be freshlydissolved each time it is used. If the salt imparts an emerald-greencolor to 100 parts of water when shaken a few times, it should berejected, unless it is found that the water contains small amounts ofammonia, which is supposed to be active in causing such a change. Fig. A, apomorphine stimulates vomiting centre in the medulla. According to Boyer and Guinard, there are two kinds of apomor-phine sold. Each has a physiological effect different from that ofthe other. The crystalline form, which is the one always to be em-ployed, causes, in overdose, irritation, spasms, trismus, vertigo, andhyperesthesia; while the amorphous form (never to be used) .causescollapse, hypothermia, general weakness, feebleness of the heart andrespiration, and anaesthesia. Physiological Action.—One of the best studies of this drug is thatof Reichert, who found that in poisonous doses it produces convulsions,and finally paralysis, both of which are chiefly spinal in origin. Nervous System.—On the nervous centres in the brain apomor-phine acts as a stimulant, but the convulsions produced by poisonousdoses are probabl
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