. Radium, X rays and the living cell. elves at the periphery of the nodules,parallel to the skin surface. It is interesting to compare thislast finding with that of Dominici, who observed a similarphenomenon in the case of irradiated normal skin of the guinea-pig (p. 160) and also in the scar tissue resulting from the regressionof certain malignant growths after irradiation (p. 265). Dominici, Rubens-Duval, Barcat and Faure-Beaulieu havemade an exhaustive series of studies upon the histological changes 262 MALIGNANT CELLS accompanyinG: the regression of malignant growths after exposureto radiu
. Radium, X rays and the living cell. elves at the periphery of the nodules,parallel to the skin surface. It is interesting to compare thislast finding with that of Dominici, who observed a similarphenomenon in the case of irradiated normal skin of the guinea-pig (p. 160) and also in the scar tissue resulting from the regressionof certain malignant growths after irradiation (p. 265). Dominici, Rubens-Duval, Barcat and Faure-Beaulieu havemade an exhaustive series of studies upon the histological changes 262 MALIGNANT CELLS accompanyinG: the regression of malignant growths after exposureto radium. The uhimate result in such a case, after successfulexposure, is the disappearance of the malignant neoplasm and itsreplacement by a relatively small amount of fibrous tissue. Atfirst sight it might appear probable that such a result was attainedby the destruction of the malignant cells, followed by ordinarycicatrisation. According to these authors, however, this is notthe case, and their researches lead them to the conclusion that. Fig. 48.—I. Section of sarcoma prior to irradiation. Magnification 97 diameter?.Dominici, Archives de Medecine Ginerale. 1909. the malignant cells themselves undergo progressive changes, re-sulting in their conversion into cells which are indistinguishablefrom normal connective tissue cells. In the case ofljymphadeno-mata and carcinoma this evolution is admittedly difticult toestablish ; with sarcomata, on the other hand, the changes areplain and capable of easy demonstration. A sarcoma described by Faure-Beaulieu and Dominici(illustrated in Figs. 48, 49, and 50) ll serve as an example ofthis process. The growth sprang from the gum of the upperjaw in the situation formerly occupied by the left canine tooth MALIGNANT CELLS 263 (which had been lost from dental caries some fifteen years pre-viously) and made its appearance about three months prior tothe commencement of treatment. Histological examination,made before irradiation was undertaken, reve
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