A text-book of practical therapeutics . lsions produced bypoisonous doses are probablyspinal. The motor and sen-sory nerves are paralyzed bypoisonous doses, and even themuscles become poisonedand incapable of doses have no effect. Circulation.—When given in moderate amounts, apomorphineincreases the rapidity and force of the pulse and raises arterial press-ure by stimulation of the accelerator nerves and the vasomotorcenters. In large doses it acts as a circulatory depressant. Respiration.—After ordinary amounts no changes in respirationoccur, but after poisonous doses th
A text-book of practical therapeutics . lsions produced bypoisonous doses are probablyspinal. The motor and sen-sory nerves are paralyzed bypoisonous doses, and even themuscles become poisonedand incapable of doses have no effect. Circulation.—When given in moderate amounts, apomorphineincreases the rapidity and force of the pulse and raises arterial press-ure by stimulation of the accelerator nerves and the vasomotorcenters. In large doses it acts as a circulatory depressant. Respiration.—After ordinary amounts no changes in respirationoccur, but after poisonous doses the breathing becomes rapid andirregular. Vomiting.—Vomiting is produced by a direct action of the drugupon the vomiting centers in the medulla, and not by an action onthe stomach. Apomorphine is, therefore, a typical centric emetic. Therapeutics.—Apomorphine is useful in nearly all cases where anemetic may be employed. In poisoning from other drugs, particu-larly depressants and narcotics, we have little knowledge of its safety,. Fig. 11.—A, apomorphine stimulates vomitingcenter in the medulla. 116 DRUGS but unless the stupor or circulatory change is very profound, thedrug may be used with care. Often a hysterical patient can bebrought to herself by an apomorphine vomit. In subacute andchronic catarrh of the stomach and air-passages it may aid in gettingrid of the mucus by emesis, and in non-emetic dose it is a usefulremedy in acute bronchitis when the secretion is very scanty. Non-emetic doses, given hypodermically, of ^ grain () have beenused as often as every three hours with notable success in producingnervous quiet in uremia, alcoholic excitement and delirium tremens, andif combined with T\$ grain of hyoscine it is particularly efficaciousin the latter states. Untoward Effects.—Apomorphine rarely causes disagreeable effects,but there are cases on record in which it has produced serious symp-toms even when given in ordinary doses. These symptoms haveconsiste
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