. Endocrinology. -•_jti ?^ ^ 1^^ Fig. 6. Uterus at time of operation. started 24 hours after operation; some were preguant and nn-suited, leaving 38 animals that could be utilized. Of these 38, 5 received Hynson, Westcott & Dunning CorpusLuteum; 4 received Ilj-nson, Westcott & Dunning Ovarian Sub-stance; 5 received Hynson, Westcott & Dunning Ovarian Resi-due ; 5 received Parke, Davis & Co. Corpus Luteum: 5 received 46 VALUE OF OVARIAN EXTRACTS Parke, Davis & Co. Ovarian Substance; 5 received Parke, Davis& Co. Ovarian Residue; 5 received Wilson Laboratories CorpusLuteum. They received from 3 to
. Endocrinology. -•_jti ?^ ^ 1^^ Fig. 6. Uterus at time of operation. started 24 hours after operation; some were preguant and nn-suited, leaving 38 animals that could be utilized. Of these 38, 5 received Hynson, Westcott & Dunning CorpusLuteum; 4 received Ilj-nson, Westcott & Dunning Ovarian Sub-stance; 5 received Hynson, Westcott & Dunning Ovarian Resi-due ; 5 received Parke, Davis & Co. Corpus Luteum: 5 received 46 VALUE OF OVARIAN EXTRACTS Parke, Davis & Co. Ovarian Substance; 5 received Parke, Davis& Co. Ovarian Residue; 5 received Wilson Laboratories CorpusLuteum. They received from 3 to 32 injections each, extendingover a period of from 14 to 85 days after operation. The ani-mals Avere killed by chloroform and the pelvic organs removed aswell as the thyroid, adrenals, pituitary and breast. In all cases the uterus showed atrophy. In the animalskilled early the atrophy was not so marked (Fig. 1, 2, 3), as inthose that were permitted to live for 2 to 3 months. The atrophy. involved the mucosa to the greatest extent (Fig. 4, 5, 6, 7). Thevilli disappear, the stroma, which is represented in most of themas a distinct entity, becomes markedly condensed. The glandsdisappear and the epithelium of the uterus is represented by onelayer of cuboidal epithelium (Fig. 7a). The musculature alsoshows slight atrophy and a marked loss of tone, the organ chang-ing its shape so that it becomes, instead of cylindrical, a collapsedtubeflatteued antero-posteriorly (Fig. 5, 7). One interesting fact noted was that the cervix did not par-ticipate in the atrophy (Fig. 8) and it would seem probable thatin the rabbit the development of the cervix was not controlledby the ovary. This, too, was true of the control castrates whichhad received no injections. It is also to be noted that in humansubjects, after a supravaginal hysterectomy and bilateral oophor-ectomy, the cervix does not undergo atrophy except when thewomen are near the menopause. The gross appearance of the j)elvic vis
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Keywords: ., bookcentury1900, bookdecade1910, booksubjectendocrinology, bookye
