The pathology and surgical treatment of tumors . hich is unknown,which endows them with a greatly augmented vegetative capacity. Inthe present state of our knowledge we must attribute this increase oftheir formative power, not to a change in the cells themselves, but toan altered condition of the tissues which they inhabit. This lattercondition we have described as a diminution of physiological resistance. An anomalous location of epithehal cells under certain conditionsmay cause carcinoma; this anomaly, however, does not constitute thereal cause, but is only an additional factor, and not an e
The pathology and surgical treatment of tumors . hich is unknown,which endows them with a greatly augmented vegetative capacity. Inthe present state of our knowledge we must attribute this increase oftheir formative power, not to a change in the cells themselves, but toan altered condition of the tissues which they inhabit. This lattercondition we have described as a diminution of physiological resistance. An anomalous location of epithehal cells under certain conditionsmay cause carcinoma; this anomaly, however, does not constitute thereal cause, but is only an additional factor, and not an essential ante-cedent condition. Every carcinoma has a benign stage. No matter where the matrixmay be located, t/ie cells composing it are at first isolated from the vas-cular tissues, and the carcinomatous stage begins with infection—that is, the growth of the tumor as a whole—is theresult of cell-migration. The new epithelial cells, like the ameba andleucocytes, possess the power of indepe?ident locomotion. The ameboid. Fig. 126.— From an epithelial carcinoma of the clitoris: epithelial nestsby small cells ; X 250 (after Perls). ibedded in a stroma infiltrated movements of carcinoma-cells were studied in 1872 by Carmalt inWaldeyers laboratory. Cells of carcinoma of the breast obtained im-mediately after amputation the material used. The cellswere detached by scraping the cut surface of the tumor, and were keptimmersed on the thermal object-table of Strieker. The isolated youngcells manifested active ameboid movements, while the deeper cells infragments of tissue remained motionless. CARCINOMA. 219 In the stroma of every carcinoma small young epithelial cellsbesides leucocytes are found (Fig. 126). This infiltration of the tissuesaround a carcinomatous tumor was called by Waldeyer the inflam-matory zone. Leucocytes escape through damaged capillary walls andare present in large number in rapidly-growing carcinoma, but amongthem young carci
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Keywords: ., bookcentury1800, bookdecade1890, booksubjectneoplas, bookyear1895
