. The endocrine organs; an introduction to the study of internal secretion . ng (chromaphil): and thegranular cells are again divisible into oxyphil and basiphil, thosestaining with acid and basic dyes respectively, the oxyphil cells beingnormally by far the more numerous. It has been suggested that thesethree types of cells represent different stages of the same cell; this isprobably only true for the chromaphobe cells and for the cells with oxyphilgranules. The last-named cells are very distinct (figs. 49 and 50, a, andfig. 51). They may sometimes be seen placed around the blood-sinuses


. The endocrine organs; an introduction to the study of internal secretion . ng (chromaphil): and thegranular cells are again divisible into oxyphil and basiphil, thosestaining with acid and basic dyes respectively, the oxyphil cells beingnormally by far the more numerous. It has been suggested that thesethree types of cells represent different stages of the same cell; this isprobably only true for the chromaphobe cells and for the cells with oxyphilgranules. The last-named cells are very distinct (figs. 49 and 50, a, andfig. 51). They may sometimes be seen placed around the blood-sinuses like Structure of the Pituitary 79 the cells of an ordinary secreting gland around the lumen of the some animals all the cells of the pars anterior are set like a columnarepithelium round blood-sinuses—this is strikingly shown in Elasmobranchfishes such as the skate. In the tortoise columnar cells surround closedvesicles containing a colloid material. The basiphil cells are, when present,mostly found near the periphery of the trabecular masses. In pregnancy. 3H ta.*£Vfcl t 4 d Flo. 50.—Section of pituitary of cat at intraglandular cleft (b), showing on theleft side (a) the highly vascular pars anterior, and on the right side ofthe cleft the pars intermedia (c), in which several vesicles are seen, andwhich abuts on the pars nervosa (d). Magnified 200 diameters. (Figs. 50,52, and 54 are from sections prepared for me by Dr M. Kojima.) large, finely granular oxyphil cells are observed in unusual number (Erdheimand Stumm): these cells have been designated pregnancy cells. Oxyphilcells are also unusually abundant in the enlarged gland of acromegalicsubjects, where they form adenoma-like masses. Most of the cells alsocontain numerous fine fatty globules. There is a small amount of reticular connective tissue between the few nerves have been traced into the pars anterior from the pars nervosa. Under certain circumstances in man and mammals, especially in cases


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