Gynecology . n the estimates of the frequency with which sarcoma-tous change takes place. This is most generally put at 5 per cent. More recentinvestigations with improved staining methods have demonstrated that manyof the diagnoses are erroneous, and that the actual proportion is nearer 1 percent. (See also Sarcoma of Uterus.) 268 GYNECOLOGY In order to make an exact diagnosis between a myoma rich in cells and a myosarcoma Raabrecommends the following points for consideration: (1) Structure of the muscular tissue and its richness in cells; (2) changes in the nuclei; (3)division of the nuclei;

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Gynecology . n the estimates of the frequency with which sarcoma-tous change takes place. This is most generally put at 5 per cent. More recentinvestigations with improved staining methods have demonstrated that manyof the diagnoses are erroneous, and that the actual proportion is nearer 1 percent. (See also Sarcoma of Uterus.) 268 GYNECOLOGY In order to make an exact diagnosis between a myoma rich in cells and a myosarcoma Raabrecommends the following points for consideration: (1) Structure of the muscular tissue and its richness in cells; (2) changes in the nuclei; (3)division of the nuclei; (4) content of intercellular fibrils (hyaline); (5) giant-cells; (6) boundariesof the tumor. Other important points are that: 1. Rich cell content and limited development of connective tissue cannot settle the diagno-sis of myosarcoma, since ordinary myomata, rich in cells, may show the same condition. 2. The nucleus in myosarcoma does not show any decided change in form in contrast tothat of ordinary 5v%.*^~ ;5 *.V v .VrfA „- y.« 1 t/

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