Practical pathology; a manual for students and practitioners . ere the condition is very far advanced some of these cells appearto be waxy, though it may be that the swollen vessels and fibres have,by pressure, caused them to become atrophied. Certain it is that thecells are not at all readily distinguished. At the periphery of theMalpighian corpuscle, the delicate waxy bands are more readily madeout, and the process may be seen to extend for a short distance in thewalls of the vascular sinuses beyond it, where there is a condition verysimilar to that met with in diffuse waxy spleen. Running t
Practical pathology; a manual for students and practitioners . ere the condition is very far advanced some of these cells appearto be waxy, though it may be that the swollen vessels and fibres have,by pressure, caused them to become atrophied. Certain it is that thecells are not at all readily distinguished. At the periphery of theMalpighian corpuscle, the delicate waxy bands are more readily madeout, and the process may be seen to extend for a short distance in thewalls of the vascular sinuses beyond it, where there is a condition verysimilar to that met with in diffuse waxy spleen. Running through the blue splenic pulp are numerous smallarterioles, the walls of which are in an advanced stage of waxy degene-ration ; the walls of some of the sinuses may also be slightly this waxy change in the wall of the sinus has once set in, there k ^AXY SAGO SPLEEN 529 is usually fatty degeneration of the endothelial cells lining the wall ofthe sinus. In this position, perhaps, better than in any other, the waxy changein the vessel may be Fig. 166.—Waxy sago spleen. Stained with alum hsemateinand van Giesons stain. ( x 70.) Enlarged Malpighian corpuscle, in which the thickened waxyarterioles may be seen stained pink. Within these the redblood corpuscles are well Central vessels, just after bifurcation ; these are not Splenic pulp unaffected by the waxy disease. Here the sinus,lined with endothelium and containing red blood corpuscles,are well seen. Note {a) that the waxy change is confined to the middle coat,especially during the early stage of the disease ; {li) that the middlecoat is picked out in patches by the disease ; {c) in these patchesthe tissues are not affected throughout, for on careful it will be seen that only between the muscle fibres does thewaxy change make its appearance, the longitudinal or transverse 530 THE SPLEEN sections of the muscle fibres being stained blue, whilst betweenthetn are red violet strea
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