. A text-book of practical therapeutics, with especial reference to the application of remedial measures to disease and their employment upon a rational basis . solubility of the compoundso formed that tannic acid is thebest antidote to the drug that wepossess. Physiological Action. — Tartaremetic, when applied to mucousmembranes, produces a burningsensation, and upon the skin itmay readily cause intense irrita-tion if the part be delicate. Ifkept in contact with a mucousmembrane, very distinct inflam-matory changes occur, and if itbe applied to the skin for anylength of time, redness, followe
. A text-book of practical therapeutics, with especial reference to the application of remedial measures to disease and their employment upon a rational basis . solubility of the compoundso formed that tannic acid is thebest antidote to the drug that wepossess. Physiological Action. — Tartaremetic, when applied to mucousmembranes, produces a burningsensation, and upon the skin itmay readily cause intense irrita-tion if the part be delicate. Ifkept in contact with a mucousmembrane, very distinct inflam-matory changes occur, and if itbe applied to the skin for anylength of time, redness, followedby acne of a pustular character,appears, which finally ends inulceration and sloughing if theuse of the drug is persisted these circumstances thevitality of the parts seems interfered with, and, as a result, healingtakes place very slowly indeed. Nervous System.—Antimony is a depressant to the sensory sideof the spinal cord and a paralyzant to all the spinal centres, motorand sensory, in poisonous dose. It is stated that when an animal is under its influence sensation toheat and acids is lost before the ordinary sense of touch is A, antimony depresses the heart-muscle; B,antimony depresses the peripheral portions ofthe vasomotor system in the bloodvessels; C,antimony depresses the vasomotor centre; D,the respiratory centre. ANTIMONY. 87 Fig. 10. The convulsions which sometimes ensue after poisonous doses in thelower animals are due to anaemia of the brain brought on by the cir-culatory depression. Ringer and Murrell have proved antimony tobe a motor-nerve and muscle poison. Circulation.—The chief influence of antimony is exerted uponthe circulation. In small doses it lowers the pulse-rate by a directdepression of the heart-muscle, and simultaneously decreases arterialtension by an action upon the peripheral portions of the vasomotorsystem in the walls of the bloodvessels, but the vasomotor influencesmay be in part centric, and this question must be c
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