. Ciba Foundation conferences on istopes in biochemistry;. Radioactive tracers in biochemistry; Isotopes -- Physiological effect. Metabolism of i*C-Labelled Steroids 13 En 1951 (R. Courrier, A. Horeau, M. Marois et F. Morel, 1951, C. R. Acad. Sci., Paris, 232, 776) une thyroxine de tres forte radioactivite sp^cifique (30 millicuries sur 12-5 mg. de thyroxine; 70 coups/minute par TTTT^Trp: de gamma au moment de I'experience) fut injeetee par voie veineuse a diverses especes animates. Les animaux traites furent sacrifies deux heures apres et Ton preleva chez eux sang, plasma, ante- hypophyse, po
. Ciba Foundation conferences on istopes in biochemistry;. Radioactive tracers in biochemistry; Isotopes -- Physiological effect. Metabolism of i*C-Labelled Steroids 13 En 1951 (R. Courrier, A. Horeau, M. Marois et F. Morel, 1951, C. R. Acad. Sci., Paris, 232, 776) une thyroxine de tres forte radioactivite sp^cifique (30 millicuries sur 12-5 mg. de thyroxine; 70 coups/minute par TTTT^Trp: de gamma au moment de I'experience) fut injeetee par voie veineuse a diverses especes animates. Les animaux traites furent sacrifies deux heures apres et Ton preleva chez eux sang, plasma, ante- hypophyse, post-hypophyse et differents organes. Les resultats peuvent se resumer ainsi: (1) La penetration de la thyroxine dans I'hypophyse varie selon les especes. (2) Chez les animaux oil le phenomene est decelable, e'est dans Yhypophyse posterieure que la thyroxine penetre davantage. II reste a determiner la signification physiologique de ce phenomene. II serait interessant d'etablir si la progesterone et I'acetate de desoxy- corticosterone radioactifs retrouves par M. Leblond dans I'hypophyse totale, se concentrent dans la posthypophyse. Heidelberger: In 1947 Jones and I did some work on the carcinogenic hydrocarbon [9:10-^*C] dibenzanthracene, and the results of our studies on excretion were very similar to those of Dr. Leblond for the steroids. I wonder whether this might be a general phenomenon, based not upon biological properties but largely upon the solubility of the compound. It is a large water-insoluble molecule. The difference in excretion pattern you observe with the deoxycorticosterone might be due primarily to its greater water-solubility. I would also like to say that we have used paper chromatographic methods for separating derivatives of carcinogenic hydrocarbons, based on a modification of Zaffaroni's procedure. Leblond: That water-insoluble molecules are more likely to be excreted in the bile, and water-soluble ones in the urine is true. Thus, thyroxine is excreted in
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