A Reference handbook of the medical sciences embracing the entire range of scientific and practical medicine and allied science . se in the connective tissue throughout the of fibrous tissue run through it from the capsuleand produce a sort of indefinite lobulation. Jlore strik-ing, liowever, is the alteration in the alveoli. Instead ofpreserving a more or less uniform roundness, they aredistorted into tlie most complicated forms, and their f \ ^^^K> I J^j^^l ^ t^^ll^^^^^^^^^^H FK). .M:i-i. (ioitre. Thyniiil lobe in seution fiimi caseillustnUfd iQ Fig. 5134. wa
A Reference handbook of the medical sciences embracing the entire range of scientific and practical medicine and allied science . se in the connective tissue throughout the of fibrous tissue run through it from the capsuleand produce a sort of indefinite lobulation. Jlore strik-ing, liowever, is the alteration in the alveoli. Instead ofpreserving a more or less uniform roundness, they aredistorted into tlie most complicated forms, and their f \ ^^^K> I J^j^^l ^ t^^ll^^^^^^^^^^H FK). .M:i-i. (ioitre. Thyniiil lobe in seution fiimi caseillustnUfd iQ Fig. 5134. walls plicated and corrugated until the outline is an ex-tremely irregular one. By many authors papillary out-growths from the walls have been described, but Ehrichclaims that these appearances are merely due to theirregular line of section of folds in the wall. The cells are irregular in height and outline, and areoften vacuolated and ragged, and contain more abundant fat globules than normal. There is much variation inthe size of the alveoli, the distended irregular ones beingfrequently long drawn out and sometimes even com. Fig. .5136.—Adenoma of Thyroid, or Colloid Goitre. municating with one another, while others are smalland so packed with cells that there is no real figures are rare. Indeed Ehrich states that pro-liferation occurs only by amitotic division, and is not aprominent feature, but that the enlargement of the glandis largely due to the distention of the alveoli. The gen-eral trend of opinion, however, is toward the idea thatthere is a hypertrophy by cell proliferation. We may pass over the histological details of the proc-ess of secretion as observed in these cases by Farner,Ehrich, Haemig, and others. Suffice it to say that whilein some cases the process of secretion seems active enough,and the alveoli are filled with a stainable colloid material,in the majority the secretion of this stainable colloid isnot evident, the cells have become high and
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