. Ciba Foundation Symposium on the Regulation of Cell Metabolism. Cell metabolism. 156 F. Dickens, G. E. Clock and P. McLean phosphate pathway. At this stage, G6P can undergo a two- stage TPN-Unked oxidation, the first oxidation yielding 6-phosphogluconolactone (Cori and Lipmann, 1952): G6P2- + TPN+ -> 6-PG lactone^- + TPNH + H+ whilst the slow hydrolysis of this lactone is then accelerated by a widely distributed but little studied lactonase (see I GLYCOGEN I <-^fGTPl ATP GLUCOSE ^^ H ME ^^^, TPN -1 ^TPNH ATPx |F6Pk ^I6PGLACT0NE| -4i \(AG;, XH^O -5. IDP J' "' 'vT^'v RECYCLING ^^ /
. Ciba Foundation Symposium on the Regulation of Cell Metabolism. Cell metabolism. 156 F. Dickens, G. E. Clock and P. McLean phosphate pathway. At this stage, G6P can undergo a two- stage TPN-Unked oxidation, the first oxidation yielding 6-phosphogluconolactone (Cori and Lipmann, 1952): G6P2- + TPN+ -> 6-PG lactone^- + TPNH + H+ whilst the slow hydrolysis of this lactone is then accelerated by a widely distributed but little studied lactonase (see I GLYCOGEN I <-^fGTPl ATP GLUCOSE ^^ H ME ^^^, TPN -1 ^TPNH ATPx |F6Pk ^I6PGLACT0NE| -4i \(AG;, XH^O -5. IDP J' "' 'vT^'v RECYCLING ^^ / \6\ (AG') \l?^(iO/—^ \?'^I? -^^ ^^}^ OAA^C; iC02j^ ylPYRUVATEl^^lLACTATEl DPNiK L^TPNH / 1?H ^^^IMALATEI —fv^ Fig. 2. Approximate free-energy changes involved in glycolysis and the hexose monophosphate oxidative pathways. Values of AG' represent free energy changes at pH 7 and are rounded to nearest 0-5 kg. (Krebs and Romberg, 1957; see also text). "Citrate, etc" and "Fumarate, etc" indicate points of linking with Krebs cycle reactions. Fig. 2); the same enzyme appears to hydrolyse S-glucono- lactone QLipmann and Brodie, 1955): 6-PG lactone^- + H2O -> G-PG^- + H+. It is unfortunate that accurate free energy values for these reactions are not available. The similar reaction with partially. Please note that these images are extracted from scanned page images that may have been digitally enhanced for readability - coloration and appearance of these illustrations may not perfectly resemble the original Ciba Foundation Symposium on the Regulation of Cell Metabolism (1958 : London, England); Wolstenholme, G. E. W. (Gordon Ethelbert Ward); O'Connor, Cecilia M. (Cecilia Mary), 1927-. Boston, Little, Brown
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