. Pathogenic micro-organisms, including bacteria and Protozoa; a practical manual for students, physicians and health officers. is purpose, alkaline broth cultures of forty-eight hours growth 230 PATHOGENIC MICRO-ORGANISMS. should be vised for the subcutaneous inoculation of amount injected should not be more than one-fifth per the body-weight of the animal inoculated, unless controls withantitoxin are made. In the large majority of cases, when the bacilliare virulent, this amount causes death within seventy-two hours. Ifa good growth is not obtained in nutrient bouillo
. Pathogenic micro-organisms, including bacteria and Protozoa; a practical manual for students, physicians and health officers. is purpose, alkaline broth cultures of forty-eight hours growth 230 PATHOGENIC MICRO-ORGANISMS. should be vised for the subcutaneous inoculation of amount injected should not be more than one-fifth per the body-weight of the animal inoculated, unless controls withantitoxin are made. In the large majority of cases, when the bacilliare virulent, this amount causes death within seventy-two hours. Ifa good growth is not obtained in nutrient bouillon, ascitic brothshould be used. At the autopsy the characteristic lesions alreadydescribed are found. Bacilli which in cultures and in animal ex-periments have shown themselves to be characteristic may be regardedas true diphtheria bacilli, and as capable of producing diphtheria inman under favorable conditions. For an absolute test of specific virulence antitoxin must be guinea-pig is injected with antitoxin, and then this and a controlanimal, with 2 of a broth culture of the bacilli to be tested; if Fir,. S7. Vincents Bacillus with accompanying Spirochaetes. the guinea-pig which received the antitoxin lives, while the controldies, it was surely a diphtheria bacillus which killed by means ofdiphtheria toxin—or, in other words, not simply a virulent bacillus,but a virulent diphtheria bacillus. When the bacilli to be testedgrow poorly in a simple nutrient bouillon they should be grown inbouillon to which one-third its quantity of ascitic fluid has been a number of bacilli have been met with which killed in doses of 2 to 15 , and yet were unaffected by anti-toxin. These bacilli, though slightly virulent to guinea-pigs, pro-duce no diphtheria toxin, and so cannot, to the best of our belief,produce diphtheria in man (see p. 206). Vincents Angina.—The local symptoms are similar to a slightcase of diphtheria. Exudate or pseudomembran
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