. The Biological bulletin. Biology; Zoology; Biology; Marine Biology. R38 Annual Report BioCurrents Research Center A part of the NIH National Center for Research Resources biomedical technology program, the BioCurrents Research Center (the successor to the National Vibrating Probe Facility) has pioneered methods in the study of transmembrane currents and. over the years since its establishment at the MBL in 1983, has hosted diverse scientific endeavors. The BioCurrents Research Center (BRC), like other Biomedical Research Technology Program centers, provides visiting investigators access to a
. The Biological bulletin. Biology; Zoology; Biology; Marine Biology. R38 Annual Report BioCurrents Research Center A part of the NIH National Center for Research Resources biomedical technology program, the BioCurrents Research Center (the successor to the National Vibrating Probe Facility) has pioneered methods in the study of transmembrane currents and. over the years since its establishment at the MBL in 1983, has hosted diverse scientific endeavors. The BioCurrents Research Center (BRC), like other Biomedical Research Technology Program centers, provides visiting investigators access to a variety of unique technologies as well as new approaches to experimentation in the biomedical sciences. All the probe technologies developed at the BRC are based on the principles of a self-referencing electrode maximizing sensitivity by noise and drift reduction. All the probes are non-invasive and generally placed in close proximity to the membrane of cells or tissues, in some cases at submicron distances. Four systems are available or being developed at the BRC. The oldest, the current probe developed in 1974, is still available for the study of external current densities resulting from the general net balance of ion transport. Most demand is for the ion-selective probes, which look at the transmembrane transport of specific ions such as calcium, potassium and protons. A most important feature of this system is its ability to detect non- electrogenic transporters. Two additional systems are now being developed, the polarographic probes and the BioKelvin probes. The former uses the chemical characteristics of molecules under applied voltages to detect their local flux. Oxygen measurement is being used to pilot this technology. The BioKelvin probe is a direct of physical principles used in materials science but extensively adapted to biological systems. It operates in air. This work, done in close collaboration with Dr. Iain Baikie of Robert Gordon University. Scot
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Keywords: ., bookauthorlilliefrankrat, booksubjectbiology, booksubjectzoology
