Interstate medical journal . having multiple nuclei. They found as a result of the transplantation of tumors, afterirradiation has been entirely stopped, that there is a tendency onthe part of the cells to return to their normal condition, but even inthe sixth generation there were many cells to be seen, showing theabnormalities (a), (b), (c), produced in the tumor-cells by theirprevious exposure to x-rays. The practical conclusion they draw isthat if the malignant cells in the human subject gradually assume 2Contamin Compt. rend. acad. d. sc., June 6, 1910. 3Marie Clunet and Raulot-Lapointe.
Interstate medical journal . having multiple nuclei. They found as a result of the transplantation of tumors, afterirradiation has been entirely stopped, that there is a tendency onthe part of the cells to return to their normal condition, but even inthe sixth generation there were many cells to be seen, showing theabnormalities (a), (b), (c), produced in the tumor-cells by theirprevious exposure to x-rays. The practical conclusion they draw isthat if the malignant cells in the human subject gradually assume 2Contamin Compt. rend. acad. d. sc., June 6, 1910. 3Marie Clunet and Raulot-Lapointe. Bull. Ass. franc,. Roue, letude du cancer, vol. IV. Pfahler: Deep Roentgenthevapy in Malignant Disease 645 less and less malignant features when exposed to x-rays this may-only be manifested at some period remote from the time of exposure. Clunet and Raulot-Lapointe have made elaborate researches intothe nature of the changes produced in malignant cells in humansubjects when subjected to x-rays. They removed sections during. the course of treatment of nineteen cases of squamous-cell carcinomaof malpighian type in the human subject. The state that, beforethe ultimate disappearance of the growth, the cells pass throughat least five successive phases which are characterized as follows:1. The latent phase. 2. Development of monstrous characters. 646 INTERSTATE MEDICAL JOURNAL 3. Keratinization. 4. Disintegration and phagocytosis. 5. Forma-tion of the connective-tissue scar. Their illustrations are most convincing of the effects of the rayson tumor cells. When sarcomatous cells are exposed to x-rays, thesame authors found that a somewhat similar transition in the cellu-lar characteristics occurs, but the latent phase, during which nochanges are observable, is very much shorter than in the other typesof malignant growth considered; instead of being from 6 to 10 days,it is generally 1 or 2 days. Nogier and Regaud4 have submitted evidence, based upon a clini-cal experience of more than
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