. The Biological bulletin. Biology; Zoology; Biology; Marine Biology. R25. Rat cardiac muscle cell. Peter J. 5. Smith PROGRAM IN MOLECULAR PHYSIOLOGY The Program in Molecular Physiology (PMP) brings together a group of resident and visiting scientists who share common interests in the molecular bases of cellular physiology. The several laboratories making up the PMP focus on cellular plasticity and the properties of molecular transport mechanisms. A variety of experimental approaches are used ranging from molecular and biochemical methodologies, through biophysics, to advanced optical and elec
. The Biological bulletin. Biology; Zoology; Biology; Marine Biology. R25. Rat cardiac muscle cell. Peter J. 5. Smith PROGRAM IN MOLECULAR PHYSIOLOGY The Program in Molecular Physiology (PMP) brings together a group of resident and visiting scientists who share common interests in the molecular bases of cellular physiology. The several laboratories making up the PMP focus on cellular plasticity and the properties of molecular transport mechanisms. A variety of experimental approaches are used ranging from molecular and biochemical methodologies, through biophysics, to advanced optical and electrochemical imaging tech- niques. An example of a research area spanning the independent laboratories within PMP is the role of metabolism and the mitochon- drion in health and disease. How, for example, does the mitochondrion contribute to insulin secretion, heme synthesis, or channel modulation? Does the aging process, targeting metabolic disorders, contribute to reproductive and neural malfunction, degeneration, and apoptosis? In addition to our interests in basic biology the laboratories of the PMP carry on a strong tradition within the Marine Biological Laboratory resident programs for instrumentation development. The BioCurrents Research Center—a national bioengineering resource of the National Institutes of Health (NCRR)—has pioneered the use of electrochemical sensors to define cellular activity through monitoring conditions in the extended boundary layer. A notable characteristic of the PMP is the extensive year-round collabo- rative outreach to regional universities and hospitals. Members contrib- ute to three Boston based NIH Program Project Grants in protein trafficking, diabetes, and anemia. Collaboration also allows the group to rapidly advance in areas of topical interest—as with an ongoing initiative to study the molecular physiology of the multi-drug resistant transporters, players of critical interest to cancer research and our understanding of infectiou
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Keywords: ., bookauthorlilliefrankrat, booksubjectbiology, booksubjectzoology
