. The Journal of laboratory and clinical medicine . Fig. 4.—Blood pressure tracing following administration of extract. dog totally diabetic, nor was the excretion of sugar followed closely sincewe wished simply to ascertain by the blood sugar whether a particular ex-tract contained the active principle or not). On December 8, 1921, Dog 35(see Chart II) was completely depancreatized. The animal made a good post-operative recovery. On December 11 we injected 6 of an extract preparedfrom the pancreas of this animal in the following way. The entire pancreasimmediately after removal was cut i
. The Journal of laboratory and clinical medicine . Fig. 4.—Blood pressure tracing following administration of extract. dog totally diabetic, nor was the excretion of sugar followed closely sincewe wished simply to ascertain by the blood sugar whether a particular ex-tract contained the active principle or not). On December 8, 1921, Dog 35(see Chart II) was completely depancreatized. The animal made a good post-operative recovery. On December 11 we injected 6 of an extract preparedfrom the pancreas of this animal in the following way. The entire pancreasimmediately after removal was cut into small pieces which were put into DtCIl. PANCREATIC EXTRACTS 4., jL per cent HCl in 95 per cent alcohol and allo\ved to stand till December10. It was then macerated, filtered, and the clear filtrate evaporated tojdryness in a warm air current. On December 11 this dry resin-like residuewas emulsified in 25 Ringers solution and 6 were given intravenouslyat 10 The blood sugar dropped from to per cent in three hours. On December 12 at 3 , 20 of an extract made from the pancreasof a cow in the same manner as outlined above, was given on an by stomach tube. The blood sugar fell from at 3 p. m. to at 7p. m. At 9 p. M., 10 of this same extract was given intravenously. The bloodsugar fell from at 9 to at 12 On December 13 (see ChartII). about 20 gm. each of liver (4), spleen (5), thyroid (6), and pancreas(7)were extracted in identically the same manner as outlined above. There wasno reduction in blood sugar following the intravenous injection of ex
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