. Ciba Foundation symposium on ionizing radiations and cell metabolism. Radiation -- Physiological effect; Cell metabolism; Radiation -- effects; Radioactivity. BEAN ROOT MERISTEM T-30 B HUMAN BONE MARROW IN CULTURE. T- 40-45. MOUSE EHRLICH ASCITES TUMOUR T»I8 Fig. 1. Mitotic cycles deduced from autoradiograph studies. Time in hours. M = metaphase; D = mitotic division; S = period of uptake of isotope into DNA; Gj and G2 = periods in early and late interphase during which DNA does not become labelled; T = total length of mitotic cycle. A. Bean root meristem. ^^p (Howard and Pelc, 1953.) B. Hum
. Ciba Foundation symposium on ionizing radiations and cell metabolism. Radiation -- Physiological effect; Cell metabolism; Radiation -- effects; Radioactivity. BEAN ROOT MERISTEM T-30 B HUMAN BONE MARROW IN CULTURE. T- 40-45. MOUSE EHRLICH ASCITES TUMOUR T»I8 Fig. 1. Mitotic cycles deduced from autoradiograph studies. Time in hours. M = metaphase; D = mitotic division; S = period of uptake of isotope into DNA; Gj and G2 = periods in early and late interphase during which DNA does not become labelled; T = total length of mitotic cycle. A. Bean root meristem. ^^p (Howard and Pelc, 1953.) B. Human bone marrow. ^^P or [8-^^C]adenine (Lajtha, Oliver and Ellis, 1954.) C. Mouse Ehrlich ascites tumour. [8-^*C]adenine (Hornsey and Howard, 1956.) mouse ascites tumour (Fig. 1 C), no G^ is observed; within 2 hours after irradiation there is a decrease in the num- ber of cells taking up [8-^^C]adenine into DNA (Hornsey and Howard, unpublished). If measured biochemically, the mitotic delay in the tumour would appear as a reduction in DNA turnover and specific activity, compared with controls, although the amount of DNA per cell would increase for a time equal to Gg (see Fig. 1), and remain slightly greater than controls until mitosis reappeared. Such effects are not. Please note that these images are extracted from scanned page images that may have been digitally enhanced for readability - coloration and appearance of these illustrations may not perfectly resemble the original Ciba Foundation; Wolstenholme, G. E. W. (Gordon Ethelbert Ward); O'Connor, Cecilia M. (Cecilia Mary), 1927-. Boston, Little, Brown
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