Nervous and mental diseases . albl., 12, S. 218. * Yirchows Archiv, Bd. 151, S. 438. 5 Pick, Deutsch. Zeit. f. Nervenh., Bd. xvii, 1900. « pjck, he. cit. LESIONS AND DISEASES OF SPINAL GRAY. 417 suggests that in some instances this natural disappearance of musclefibers may, from prenatal or other cause, exceed physiological limits andproduce progressive dystrophy. The flabby and wasted muscles of oldage may be in part due to a similar cause. Age.—The great majorityof cases appear before puberty is established, with especial frequencyduring the second dentition and at pubescence. Others are fir
Nervous and mental diseases . albl., 12, S. 218. * Yirchows Archiv, Bd. 151, S. 438. 5 Pick, Deutsch. Zeit. f. Nervenh., Bd. xvii, 1900. « pjck, he. cit. LESIONS AND DISEASES OF SPINAL GRAY. 417 suggests that in some instances this natural disappearance of musclefibers may, from prenatal or other cause, exceed physiological limits andproduce progressive dystrophy. The flabby and wasted muscles of oldage may be in part due to a similar cause. Age.—The great majorityof cases appear before puberty is established, with especial frequencyduring the second dentition and at pubescence. Others are first mani-fest during adolescence, from eighteen to twenty-six years of age; anda rapidly diminishing series is encountered later in life. It sometimeshappens that, appearing at adult years in one generation, the myopathyfollows in early childhood in the next. As males are rendered impo-tent by the disease, its transmission necessarily falls to those femalesof the family who escape and reach maturity. In addition, boi/s seem. Figs. 159 and 160.—Scapulohumeral type oi progressive nuiscular atrophy. Note the angle on rightside of neck with lengthening of the neck, due to wasting of the trapezius, and the peculiarity of thedeltoid. more frequently affected than (jirls. Appearing commonly during theyears of childhood, it often follows the diseases peculiar to that periodof life, but it is difficult to assert their causative activity. In somecases diphtheria has seemed to lead to it; in others it has followedexposures to cold, slight injuries, and infections. Given a neuronfeebly endowed with enduring qualities, it is not improbable that anycondition capable of reducing the general health, or any toxic state mayact upon it with unusual virulence. Morbid Anatomy.—The muscles show various morphologicalchanges, depending upon the presence of hypertrophy, pseudohyper-trophy, or atrophy,—the final and logical end for all the affected sarcode elements may be hypertrophi
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