Archives of internal medicine . suspension of tuberculinic acid. The only HAYEK EMERSOy 453 new error to be tested for or explained in this experiment was the useof alcohol in the solution of the dried tubercle powder. As a control,alcohol, in the amounts used in testing the dissolved extract, was injectedin 50 per cent, and 95 per cent, strengths into the veins, and recordswere taken (Fig. 4). One of 95 per cent, alcohol caused a drop incarotid pressure from 120 mm. to 106 mm. Hg, and a depressed heartaction with a complete recovery in fifty-five seconds from the time ofthe injection. On
Archives of internal medicine . suspension of tuberculinic acid. The only HAYEK EMERSOy 453 new error to be tested for or explained in this experiment was the useof alcohol in the solution of the dried tubercle powder. As a control,alcohol, in the amounts used in testing the dissolved extract, was injectedin 50 per cent, and 95 per cent, strengths into the veins, and recordswere taken (Fig. 4). One of 95 per cent, alcohol caused a drop incarotid pressure from 120 mm. to 106 mm. Hg, and a depressed heartaction with a complete recovery in fifty-five seconds from the time ofthe injection. One of the alcoholic extract of tubercle powder in 95 per cent,alcohol caused a drop in carotid pressure from 148 mm. to 106 mm.,with extreme arterial relaxation and a return to normal only after fiveminutes (Fig. 5). Five-tenths of a cubic centimeter of the alcoholic extract caused adrop from 135 mm. to 106 mm. in carotid pressure, and a return to pre-vious pressure and arterial tone only after one and a half minutes ( Fig. 4.—Effect of 1 95 per cent, alcoliol administered intravenously on ether-ized cat. Note the depressed heart action accompanying tlie fall in carotid records are as described in Figure 1. 6). E\en of the alcoholic extract showed a fall in carotid pres-sure from 140 mm. to Vo4 mm. in thirty seconds. No effect was observed as a result of the use of tuberculinic acid ; gm. in suspension in 1 of water. A last experiment was made with an etherized dog. No result wa-obtained from a solution of tuberculinic acid; in 1 decinonnalsodium hydroxid. The same niaiked vasodilator efl^ect was observed from the use ofalcoholic extract of the dry powder, as was seen in the previous experi-ment with the cat. The usual extreme depression Avas noted with amannite cultuie. The use of 5 mg. of Eacillen-Emiihion pioved effective in giving amarked fall from 110 mm. to 86 mm., with evidences of vasodilatation,although small
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