. A manual of diseases of the nervous system. howed distension of capillaries andminute extravasations in thegrey substance, swelling ofthe neuroglial elements andof the ganglion-cells, whichwere granular with indistinctprocesses. Another importantearly observation is that ofDr. Charlewood Turner,t sixweeks after the onset (). In this and othersomewhat later cases, acutechanges have been found inthe anterior cornua, moreadvanced than in Drum-monds case. They are oftenwidely spread in slight de-gree, and attain considerableintensity in one or more foci,usually in the cervical orlumbar en
. A manual of diseases of the nervous system. howed distension of capillaries andminute extravasations in thegrey substance, swelling ofthe neuroglial elements andof the ganglion-cells, whichwere granular with indistinctprocesses. Another importantearly observation is that ofDr. Charlewood Turner,t sixweeks after the onset (). In this and othersomewhat later cases, acutechanges have been found inthe anterior cornua, moreadvanced than in Drum-monds case. They are oftenwidely spread in slight de-gree, and attain considerableintensity in one or more foci,usually in the cervical orlumbar enlargements or these spots the anteriorhorn is softened ; sometimesthere is hsemorrhagic infiltra-tion, sometimes an actualcavity (Fig. 112, A, b). Themicroscope shows extrava-sated blood, often massedalong the vessels (Fig. 112,c), and scattered through thegrey matter with other cellssuch as are met with in mye-litis. There are also granulecorpuscles and other productsof degeneration of the nerve-elements. These elements, >KU f ^\. Fig. 112.—Acute anterior polio-myelitis In achild 2^ years old, six weeks after the onset.(After Charlewood Turner.) A. Sectionthrough the lowest part of the lumbar en-largement, showing a cavity visible to thenaked eye, on the left side. B. Left ante-rior half of the cord under a low magnify-ing power, showing destruction of almostthe whole anterior cornu. c. Portion ofanterior cornu in the upper part of thelumbar enlargement. Numerous corpuscleslie in the granular protoplasm and reticulumof fine fibres. A small artery is encrustedwith several layers of corpuscles and nuclei. and especially the motor nerve-cells, have almost entirely disappeared. Wliere the change isslighter in degree there is a leucocytal infiltration, a few granulecorpuscles are seen, while the nerve-cells may be structurally intact,but swollen, and granular. The morbid appearances may be con-* Brain/ April, 1885. f Path. vol. xxv, p. 203. 366 SPINAL CORD. fin
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