. The thyroid gland in health and disease. as the toxins of this organism were shown byexperiment to be capable of producing tetanic spasms in dogs,and of causing the most marked destructive changes in the thyroidgland (fig. 9). [8, 9, 10, 11.] While there is at present no conclusive evidence that any oneof the organisms whose vaccines have been employed in thetreatment of goitre has a specific influence in the production ofthe endemic form of this disease, it is well proven that they allpossess in greater or lesser degree the power to induce hyper-plastic and, in the case of the spore-bearing
. The thyroid gland in health and disease. as the toxins of this organism were shown byexperiment to be capable of producing tetanic spasms in dogs,and of causing the most marked destructive changes in the thyroidgland (fig. 9). [8, 9, 10, 11.] While there is at present no conclusive evidence that any oneof the organisms whose vaccines have been employed in thetreatment of goitre has a specific influence in the production ofthe endemic form of this disease, it is well proven that they allpossess in greater or lesser degree the power to induce hyper-plastic and, in the case of the spore-bearing organism, fibroticchanges in the thyroid gland. It is quite possible, therefore,that in certain cases any one of these organisms may be the actualexcitant of thyroid enlargement. Such cases are those associated 110 ENDEMIC GOITRE with definite symptoms of intestinal toxaemia and stasis, to whichI shall refer at greater length under the term Toxsemic must exist, however, a specific organism of endemic goitre. fmmt^.^^grmf^-. Fig. 37.—Before treatment, 385 cm. Fig. 38.—After treatment, 36 cm. Case of endemic goitre treated with autogenous mixed vaccine containingcoliform organisms from the intestine. 0/ T>Ay OF Twe^TMfiivT. 7 ^ 7 /o ^s 30 ^ 37-S 66-6-36 A \ V A \ N. 1 V —©— r 1 7^ Fig. 39.—Chart showing measurements of neck at various stages of treatment,with doses and times of administration of the vaccine. and on the assumption that no one of the vaccines which I haveemployed contains this organism, my explanation of their action VACCINE TREATMENT 111 would be that, by aiding the disappearance of secondary infec-tions, they relieve the thyroid of part of its abnormal burdenand enable it, without continuing in a state of hypertrophy.
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