Archives of internal medicine . id changes are the result of a systemic disturbance instead of thecause of the systemic disturbance. 5. It does not seem possible at the present time to distinguish or toseparate, solely by anatomical studies, those thyroid hyperplasias whichshould be considered as tumors from those which should be designated asphysiological or compensatory hyperplasias. This fact is implied in theuse of such terms as adenomatous or adeno-parenchymatous goiters. 6. The thyroid undergoes exceedingly rapid histological changes thecauses for which are still ill understood. Thus an
Archives of internal medicine . id changes are the result of a systemic disturbance instead of thecause of the systemic disturbance. 5. It does not seem possible at the present time to distinguish or toseparate, solely by anatomical studies, those thyroid hyperplasias whichshould be considered as tumors from those which should be designated asphysiological or compensatory hyperplasias. This fact is implied in theuse of such terms as adenomatous or adeno-parenchymatous goiters. 6. The thyroid undergoes exceedingly rapid histological changes thecauses for which are still ill understood. Thus an active hype%lasiawith high columnar epithelium and no stainable colloid may change to 508 THE ARCHIVES OF I\TER\AL MEDIVISE a colloid s^land with low cnhic-al o]) and abundant colloid in fromtwo to three weeks. All these factors introduce grave ditticulties in the way of establishingthe major and fundamental types of thyroid changes. Xevertheless, bythe utilization of material from Imiiian autopsies and from the lower. Y\cr 2.—^Marked glandiilar liypeiplasia. (liuinan). Note the reduced colloid;the liigli colunuiar epithelium: the increased stroma: the enlarged and irregulaifollicles.
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