. The thyroid gland in health and disease. id gland from a 4-day-oldrat. From same case as fig. 49, which shows the normal isthmus. X 180. severity of the tetanoid symptoms was directly proportional tothe severity of the pathological changes in the attributed the haemorrhages into the parathyroids to injuryat birth, but in the light of my experimental findings in ratsthese haemorrhagic lesions are to be attributed not to traumaat birth but to the action on the foetal glands of the highlyvirulent products of anaerobic organisms in the maternal findings appear to
. The thyroid gland in health and disease. id gland from a 4-day-oldrat. From same case as fig. 49, which shows the normal isthmus. X 180. severity of the tetanoid symptoms was directly proportional tothe severity of the pathological changes in the attributed the haemorrhages into the parathyroids to injuryat birth, but in the light of my experimental findings in ratsthese haemorrhagic lesions are to be attributed not to traumaat birth but to the action on the foetal glands of the highlyvirulent products of anaerobic organisms in the maternal findings appear to me to indicate that the factors in the PARATHYROID DISEASE 155 origin of tetany are (1) a toxic substance which wholly, or moreusually partially, destroys the parathyroid and which, as a rule,injures the thyroid at the same time, and (2) a toxic irritantwhich by its action on the central nervous system gives rise tothe symptoms. It is very probable that the same toxic substancewhich destroys the parathyroid may also act as the irritant of. Fig. 69.—Section of thyroid and parathyroid from a 4-day-old rat, showingslight hyperplasia and some fibroblastic invasion in the former. The parathyroidis almost wholly destroyed by haemorrhage into its substance. From the same caseas fig. 50, showing marked hyperplasia and fibrosis of isthmus, the lateral lobesbeing but slightly involved. X 180. the central nervous system. It is probable also that the parathy-roid lesions are usually congenital and that symptoms of tetanywill not arise until an organism has been implanted in the bowelwhich is capable of producing the essential—and it may bespecific—nerve irritant. It is possible also that the para-thyroids may in the presence of this specific irritant be relatively 156 PARATHYROID DISEASE AND TETANY incompetent though not grossly diseased. And it may be thatthe hypersensitive state of the nerves which disturbance of thecalcium metabolism, consequent on thyro-parathyroid incom-petency,
Size: 1586px × 1575px
Photo credit: © The Reading Room / Alamy / Afripics
License: Licensed
Model Released: No
Keywords: ., bookcentury1900, bookdecade1910, bookpublishernewyorkwilliamwood
