The Cleveland medical journal . e cells which form the membrane greatly resemble osteoblasts. Ruh—Metaplastic Bone and Marrow Formation 733 The marrow occurs intimately associated with osseous tissue. Figure (5). In no place is marrow found in which bone cannot be found in the immediate neighborhood. All types of marrow cells are present here. Myelocytes are very numerous, whilenucleated red blood corpuscles are not uncommon, Figure (6), and giant cells are frequently found, Figure (7). Occasionallylarge mononuclear cells containing pigment are encountered. Considerable experimental
The Cleveland medical journal . e cells which form the membrane greatly resemble osteoblasts. Ruh—Metaplastic Bone and Marrow Formation 733 The marrow occurs intimately associated with osseous tissue. Figure (5). In no place is marrow found in which bone cannot be found in the immediate neighborhood. All types of marrow cells are present here. Myelocytes are very numerous, whilenucleated red blood corpuscles are not uncommon, Figure (6), and giant cells are frequently found, Figure (7). Occasionallylarge mononuclear cells containing pigment are encountered. Considerable experimental work has been done on metaplasticbone formation and not a little has been added to our knowledgeas to the conditions under which bone formation takes and Frattin (17) produced bone formation in the kid-ney by the ligation of the renal artery. They found calcium de-posits in the necrotic tissue with a growth of vascular granulationtissue into the kidney springing from the capsule, and containingosseous Fig. 6. Marrow; showing the various types of cells. Hematoxylin and eosin x 500. Poscharrisky (3) repeated the experiments of Sacerdotti an4Frattin and found bone in three out of five animals used in hisexperiments. In Maximows (18) experiments formation occurred in fiveweeks. He also states that such deposits may disappear withina year. Liek (19), after ligating the renal artery and wrapping thekidney in omentum to secure a free collateral circulation, obtainedbone formation in the region of the renal pelvis within sixteen totwenty days; without free collateral circulation it required aboutthree months for ossification to appear. Metaplasia has long been a subject compelling the attention 734 The Cleveland Medical Journal of pathologists and physiologists. Great care must be taken incalling a process one of metaplasia, for the distinctions betweenthe various processes of true growth are not as sharply definedas we oftimes are led to believe. Metaplasia
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