. The thyroid gland in health and disease. of additionalexperimental and epidemiological research, which has definitelydemonstrated that neither chemical constituents of the water,geological peculiarities of the soil, nor factors of nutrition areprimarily responsible for the genesis of this disease. It is un-questionably true that these influences may favour its develop-ment, and in this respect nutritional factors operate in markeddegree, but that the true prima causa of endemic goitre is a livingorganism is now generally admitted by the majority of those whohave devoted special attention to


. The thyroid gland in health and disease. of additionalexperimental and epidemiological research, which has definitelydemonstrated that neither chemical constituents of the water,geological peculiarities of the soil, nor factors of nutrition areprimarily responsible for the genesis of this disease. It is un-questionably true that these influences may favour its develop-ment, and in this respect nutritional factors operate in markeddegree, but that the true prima causa of endemic goitre is a livingorganism is now generally admitted by the majority of those whohave devoted special attention to its experimental and epidemio-logical study. CAUSAL AGENT OR AGENTS OF GOITRE 93 The proof of the infectious nature of goitre may be sum-marized as follows :— (1) In villages where goitre prevails, and which are situatedone above the other on an unprotected water-supply,such as a mountain stream, goitre shows a steady in-crease in prevalence from above downwards, this increasebeing dependent upon the increased impurity of thewater. [1.].


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Keywords: ., bookcentury1900, bookdecade1910, bookpublishernewyorkwilliamwood