. Ciba Foundation Symposium on the Regulation of Cell Metabolism. Cell metabolism. 248 Van R. Potter and Hermann Niemeyer results were in agreement with an inhibition of phospho- hexoisomerase. If 6-PG plays any role in the mechanism of TPN action, one has to show that there is an accumulation of 6-PG under our experimental conditions. The prerequisite for such an accumu- lation is present in the system, since the assays indicated that the G-6-P dehydrogenase is more active than the 6-PG E fO >- z UJ o ^â ^ o \- G-6-P: .113 6-PG: .050 » (44%) GLUCOSE-6-PHOSPHATE
. Ciba Foundation Symposium on the Regulation of Cell Metabolism. Cell metabolism. 248 Van R. Potter and Hermann Niemeyer results were in agreement with an inhibition of phospho- hexoisomerase. If 6-PG plays any role in the mechanism of TPN action, one has to show that there is an accumulation of 6-PG under our experimental conditions. The prerequisite for such an accumu- lation is present in the system, since the assays indicated that the G-6-P dehydrogenase is more active than the 6-PG E fO >- z UJ o ^â ^ o \- G-6-P: .113 6-PG: .050 » (44%) GLUCOSE-6-PHOSPHATE 6-PHOSPHOGLUCONATE (3/jM) ^TIME (minute'^ Fig. 14. Glucose-6-phosphate and 6 phosphogluconic dehydrogenase activities in brain supernatant fraction. The curve indicated by "Glucose-6-phosphate" re- presents the activity of glucose-6-phosphate dehydro- genase, corrected for the activity on 6-phosphoglucon- ate, as described by Clock and McLean (1954). dehydrogenase (Fig. 14). This relationship had also been shown by Glock and McLean (1954) and more recently by McNair Scott (1958). Preliminary experiments have shown that 6-PG accumulates in the presence of TPN, but not in its absence, with or without mitochondria. Discussion The experimental data support the conclusion that in the brain system the presence of TPN can change the rate of. Please note that these images are extracted from scanned page images that may have been digitally enhanced for readability - coloration and appearance of these illustrations may not perfectly resemble the original Ciba Foundation Symposium on the Regulation of Cell Metabolism (1958 : London, England); Wolstenholme, G. E. W. (Gordon Ethelbert Ward); O'Connor, Cecilia M. (Cecilia Mary), 1927-. Boston, Little, Brown
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