. Bulletin of the Department of Agriculture. Agriculture; Agriculture. BULLETIN No. 306 % â S&?m<&~ri* Contribution from the Bureau of Plant Industry WM. A. TAYLOR, Chief. jV£?"^Wt» Washington, D. C. PROFESSIONAL PAPER. October 15, 1915 SOME EFFECTS OF SELECTION ON THE PRODUCTION OF ALKALOIDS IN BELLADONNA. By A. F. Sieveks, Chemical Biologist, Drug-Plant and Poisonous-Plant Investigations. CONTENTS. Introduction 1 Selection of typical plants 2 Method of controlling pollination 2 First-generation plants from cross-pollinated parents 3 Comparison of first-generation plant
. Bulletin of the Department of Agriculture. Agriculture; Agriculture. BULLETIN No. 306 % â S&?m<&~ri* Contribution from the Bureau of Plant Industry WM. A. TAYLOR, Chief. jV£?"^Wt» Washington, D. C. PROFESSIONAL PAPER. October 15, 1915 SOME EFFECTS OF SELECTION ON THE PRODUCTION OF ALKALOIDS IN BELLADONNA. By A. F. Sieveks, Chemical Biologist, Drug-Plant and Poisonous-Plant Investigations. CONTENTS. Introduction 1 Selection of typical plants 2 Method of controlling pollination 2 First-generation plants from cross-pollinated parents 3 Comparison of first-generation plants from cross-pollinated and close-pollinated parents 6 Second-generation plants from cross-pollina- tion 11 Reproduction of selected plants from cuttings 18 Conclusions 19 INTRODUCTION. The improvement of many of our important agricultural crops has been brought about by means of plant selection and breeding, and similar methods are being extended to various other fields of plant production in the hope of achieving similar results. With a few exceptions, the growing of medicinal plants is still in its early stages, and it is a much-debated question whether these plants when cultivated lose any of their therapeutic properties; but with the constantly diminishing supply of many of our important native drug plants cultivation becomes more and more imperative. Also, the quality of some of the drugs on the market has deteriorated to such an extent that improvement is much to be desired, and it is hoped that this may be accomplished through the methods employed by the plant breeder. Atropn belladonna is an important mydriatic drug, the supply of which has been of such inferior quality in recent years that the Office of Drug-Plant and Poisonous-Plant Investigations has been conducting experiments for some time with special reference to in- creasing the alkaloidal content of the plant. The first step was to a general study of the plant with regard to individual variation 69
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