. The Biological bulletin. Biology; Zoology; Biology; Marine Biology. FERTILIZATION AND DEVELOPMENTAL BIOLOGY 293 100 90 80 70 60 50 30 20 10 0 B B T // / / O O T- O UJ ~ i- O m ppm. Figure 1 (A) Dose-response relationship of the mortality ofdechono- naled zehrali \h embryos exposed to benzene (B), toluene (T). and a SO/ 50 mixture of both (B+T). (B) Videoprinl of embryo exposed for 30 minutes to a 50/50 mixture of ppm benzene and toluene at the gastnda stage. Photo taken 48 k post fertilization (hpj). Note general stunted development and pericardia/ edema (arrow) when compared to the c
. The Biological bulletin. Biology; Zoology; Biology; Marine Biology. FERTILIZATION AND DEVELOPMENTAL BIOLOGY 293 100 90 80 70 60 50 30 20 10 0 B B T // / / O O T- O UJ ~ i- O m ppm. Figure 1 (A) Dose-response relationship of the mortality ofdechono- naled zehrali \h embryos exposed to benzene (B), toluene (T). and a SO/ 50 mixture of both (B+T). (B) Videoprinl of embryo exposed for 30 minutes to a 50/50 mixture of ppm benzene and toluene at the gastnda stage. Photo taken 48 k post fertilization (hpj). Note general stunted development and pericardia/ edema (arrow) when compared to the control. Magnification bar ( mm) same as control \liomi in 1C Forty-eight lipl control animal. Magnification bar= mm lowing chemicals: benzene, toluene, and a mixture of the two. The concentrations of benzene and toluene in the ERS ranged from 10 parts per million (ppm) to ppm, and the con- centrations in mixtures of benzene and toluene were in a sim- ilar range. Equal volumes of equal concentrations of benzene and toluene were combined to provide a series of 50-50 mix- tures. As the concentration of benzene, toluene, and the mix- tures increased, so did the mortality (Fig. 1A). In this prelimi- nary study, the slopes of the curves in Figure 1A are similar. However, at the highest concentration (10 ppm), the slope of the combination of benzene and toluene declines; the signifi- cance of this effect will be determined in future experiments. Dechorionated gastrula-stage embryos were immersed in different toluene concentrations for 30 min. and the lethal con- centration that killed 50% of the animals (LC5U) was found ( ppm). Benzene, tested in this manner, had an LC50 of ppm, but the mixture of benzene and toluene had an LC50 of about ppm. Therefore, the combination of benzene and toluene is acting synergistically; at intermediate doses, the mixture is more toxic to the embryos than either benzene or toluene alone (Fig. 1A). [TCDD(2,3,7,8,tetrachIo
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Keywords: ., bookauthorlilliefrankrat, booksubjectbiology, booksubjectzoology
