. The elements of pathological histology with special reference to practical methods . Fig. 176.—Large-Round-Celled Sarcoma of the Cranium, with Absorption ofTHE Bone, x 240. (Hsematoxylin and cosin.) a, Bone with ; b, How-ships lacunpe, with osteoclasts ; c, Large round cells of the sarcoma. certain morbid conditions of the nervous system, and an atrophydue to inflammation of the marrow and periosteum. In all thesevarieties the atrophy advances, like physiological absorption of bone,by the formation of pitted depressions, semicircular lacunae (ffoivshipslacunce), wherein lie
. The elements of pathological histology with special reference to practical methods . Fig. 176.—Large-Round-Celled Sarcoma of the Cranium, with Absorption ofTHE Bone, x 240. (Hsematoxylin and cosin.) a, Bone with ; b, How-ships lacunpe, with osteoclasts ; c, Large round cells of the sarcoma. certain morbid conditions of the nervous system, and an atrophydue to inflammation of the marrow and periosteum. In all thesevarieties the atrophy advances, like physiological absorption of bone,by the formation of pitted depressions, semicircular lacunae (ffoivshipslacunce), wherein lie large polynuclear cells (osteoclasts, Fig. 176, h) OSTEOMALACIA 855 which show their activity by solution of the bone-substance. Shouldthis solution take place over a wider extent, and be complete, cystsmay even form in the bone. Osteomalacia (Fig. 177) is a special variety of atrophy whichoccurs in more advanced life, but is most frequent in women duringpregnancy and child-bed, and which consists in a decalcification of a. ^-^ Fig. 177.—Senile Osteomalacia of the Rib. x 70. (Hajmatoxylin and eosin.)o, Periosteum ; h. Thicker calcified trabecula; of bone ; c, Very thin bony trabcculaj inprocess of decalcification ; d, Decalcified osseous tissue, rich in cells ; e, Marrow composedof round and fat-cells. the bone. This always begins from the medullary cavity or fromthe cancellous spaces and Haversian canals, , at the periphery ofthe bony trabecular, and gradually advances towards the axis of thelatter. The decalcified part {d) shows a striped or fibrous interstitialsubstance, in which the earlier lamellar stratification can sometimesstill be made out, whilst the bone corpuscles are in part retained, butin part have lost their processes or even entirely disappeared. The 350 THE OSSEOUS SYSTEM line of demarcation between the decalcified and normal bone isvery sharp, but sometimes shows incurvings resembling Howshipslacunse. When the decalcifying process steadily progresses,
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Keywords: ., bookcentury1800, bookdecade1890, booksubjectpatholo, bookyear1895
