. Ciba Foundation symposium on drug resistance in micro-organisms: mechanisms of development. Drug resistance in microorganisms. 146 M. J. Thornley, J. Sinai and J. Yudkin 9- o6 c 0- j 3 1 O 7- 1 O 1 4- / /' (N 3^ / ' cn / / 3 = 1 1 , j/ 0; o C 3 I. 2 3 4 5 6 7 Time (hours Fig. 3. Effect of proflavine additions at different phases of cultural growth on resistance of Esch. coli 36. Flask 1—Proflavine additions start in lag phase 30 min. after inoculation Flask 2—Proflavine additions start in lag phase 45 min. after inoculation Flask 3—Proflavine additions start in late logarithmic phase 5J hrs.
. Ciba Foundation symposium on drug resistance in micro-organisms: mechanisms of development. Drug resistance in microorganisms. 146 M. J. Thornley, J. Sinai and J. Yudkin 9- o6 c 0- j 3 1 O 7- 1 O 1 4- / /' (N 3^ / ' cn / / 3 = 1 1 , j/ 0; o C 3 I. 2 3 4 5 6 7 Time (hours Fig. 3. Effect of proflavine additions at different phases of cultural growth on resistance of Esch. coli 36. Flask 1—Proflavine additions start in lag phase 30 min. after inoculation Flask 2—Proflavine additions start in lag phase 45 min. after inoculation Flask 3—Proflavine additions start in late logarithmic phase 5J hrs. after inoculation Flask 4—Proflavine additions start in late logarithmic phase 4 hrs. after inoculation Flask 5—Proflavine additions start in middle logarithmic phase 2| hrs. after inoculation Flask 6—Control for flask 1 Flask 7—Control for flasks 2, 3, 4, and 5 Flask 8—Control for flasks 3 and 4 Log2 of optical density and increase in resistance plotted against time proflavine added gradually # flask 5 growth in flask 1 and 6 expressed as logg viable count no proflavine added Time from Please note that these images are extracted from scanned page images that may have been digitally enhanced for readability - coloration and appearance of these illustrations may not perfectly resemble the original Ciba Foundation; Wolstenholme, G. E. W. (Gordon Ethelbert Ward); O'Connor, Cecilia M. (Cecilia Mary), 1927-. Boston, Little, Brown
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