. Ciba Foundation Symposium on the Regulation of Cell Metabolism. Cell metabolism. 102 Britton Chance sevenfold (Chance, 1956). Proof that the deceleration of respiration is due to the restitution of respiratory control and not to an unknown inhibition of electron transfer is demons- trated by the fact that ADP addition gives an even more rapid respiratory rate (a 14-fold increase). To determine the magnesium concentration needed for aerated. medium |> 400^M ADP 6mM \ \\ ^[0^] =0^ Fig. 8. An illustration of the increased respiratory control occasioned by the addi- tion of magnesium to rat l
. Ciba Foundation Symposium on the Regulation of Cell Metabolism. Cell metabolism. 102 Britton Chance sevenfold (Chance, 1956). Proof that the deceleration of respiration is due to the restitution of respiratory control and not to an unknown inhibition of electron transfer is demons- trated by the fact that ADP addition gives an even more rapid respiratory rate (a 14-fold increase). To determine the magnesium concentration needed for aerated. medium |> 400^M ADP 6mM \ \\ ^[0^] =0^ Fig. 8. An illustration of the increased respiratory control occasioned by the addi- tion of magnesium to rat liver mitochondria suspended in sucrose-EDTA-phosphate med- ium. Mw= mitochondrial suspension. (Expt. no. 474b) (From Chance, 1956. Reproduced by permission of the Editors, Proc. Ill int. Congr. Biochem.) restoration of half-maximal respiratory control in the suspen- sion described above, we have plotted, in Fig. 9, the respira- tion rate for a number of magnesium concentrations. As shown in Fig. 8, the addition of 6 mM magnesium causes a maximal deceleration of respiration of more than sevenfold. Half-maximal effect is obtained with roughly 0-5 mM mag- nesium. Thus, inhibition of respiratory activity can be obtained by additions of low concentrations of magnesium to the mitochondria. Cyclic responses of respiratory activity have not been demonstrated for increases and decreases of magnesium concentration, as they have for ADP (Fig. 4). However, it is reasonable to assume that such responses would. Please note that these images are extracted from scanned page images that may have been digitally enhanced for readability - coloration and appearance of these illustrations may not perfectly resemble the original Ciba Foundation Symposium on the Regulation of Cell Metabolism (1958 : London, England); Wolstenholme, G. E. W. (Gordon Ethelbert Ward); O'Connor, Cecilia M. (Cecilia Mary), 1927-. Boston, Little, Brown
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