The Biochemical journal, 1907 . egained its natural colour, withthe exception of the digitations which are all intensely black, and drying at thetips, as much as 0*5 cm. being dry and shrivelled. ^•^- Hypodermic injection of a further 10 mgms. of ergotoxine in 80 per cent,alcohol. The effects were again similar, and the gangrenous process was found tohave advanced on the 21st, when a further 10 mgms. were injected. After thislast injection the hinder part of the comb remained dark in colour till the 25th,when 20 mgms. were injected in similar solution. The whole comb then remaineddark pu
The Biochemical journal, 1907 . egained its natural colour, withthe exception of the digitations which are all intensely black, and drying at thetips, as much as 0*5 cm. being dry and shrivelled. ^•^- Hypodermic injection of a further 10 mgms. of ergotoxine in 80 per cent,alcohol. The effects were again similar, and the gangrenous process was found tohave advanced on the 21st, when a further 10 mgms. were injected. After thislast injection the hinder part of the comb remained dark in colour till the 25th,when 20 mgms. were injected in similar solution. The whole comb then remaineddark purple for forty-eight hours, when the effect again gradually receded, leavingpractically the whole of the part of the comb behind the root black and , with the last three digitations, was shed in one piece about a fortnight tips of the digitations anterior to this were similarly 6 shows a photograph of this bird taken in the following March, when the combwas beginning to grow again. ??^.. Fig. 6 Cock, with comb reduced by gangrene (see text). The shape of the comb before the experiment is roughly outlined. Throughout this experiment the bird exhibited no well-developed ataxia, no disorderof the digestive tract, and apart from the effect on the comb, remained practically innormal health. ERGOTOXINE AND CONSTITUENTS OF ERGOT 269 The resemblance between the effects of this administration ofergotoxine, by a method ensuring slow absorption, to those obtainedby Robert with sphacelinic acid given in initially small but graduallyincreasing doses, is very striking. The effects in the earlier experi-ments, on the other hand, when the ergotoxine was injected in water-soluble form, arc more reminiscent of those which he obtained withlarge initial doses of sphacelinic acid. It follows that Roberts conclusions as to the part played bysphacelinic acid in the epidemics of ergotism can, for the most part,at any rate, be transferred to ergotoxine. We are not
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