Archives of internal medicine . gm. 1,9201,,0161,,490 1, AcidosisIndex. 6 510 8 71312 Date. 4/17/094/28/095/13/095/27/0911/ 2/094/21/105/28/10 UrineQuantity Ammonia Index. ,,9202,4004,4405,7605,760 3,458 4. 1481312133520 thee an^h-sef * ? ? ? ^ ^^^^^^«- ^ -^^^-g - P-t of 372 THE ARCHIVES OF INTERNAL MEDICINE Table 3.—Final Month of a Case of Diabetes Ending in Collapse 5 ^- O Oi . S S>..S^ Q sa Date. O OS1 Ac ?but raici a teo . o a •^^c ?3 5-^2 O2 rtl a oODo o ii^ 5 <j o


Archives of internal medicine . gm. 1,9201,,0161,,490 1, AcidosisIndex. 6 510 8 71312 Date. 4/17/094/28/095/13/095/27/0911/ 2/094/21/105/28/10 UrineQuantity Ammonia Index. ,,9202,4004,4405,7605,760 3,458 4. 1481312133520 thee an^h-sef * ? ? ? ^ ^^^^^^«- ^ -^^^-g - P-t of 372 THE ARCHIVES OF INTERNAL MEDICINE Table 3.—Final Month of a Case of Diabetes Ending in Collapse 5 ^- O Oi . S S>..S^ Q sa Date. O OS1 Ac ?but raici a teo . o a •^^c ?3 5-^2 O2 rtl a oODo o ii^ 5 <j o H < ca gm. gm. gm. gm. 11/30/08 63 58 60 12/ 2/08 4,680 62 51 60 12/ 6/08 4,470 69 47 24 12/ 8/08 4,050 62 36 50 12/10/08 3,150 55 30 25 12/13/08 2,040 31 20 25 12/15/08 1,800 24 16 0 12/17/08 1,800 20 14 0 12/21/08 2,310 36 17 10 12/24/08 2,550 28 20 10 12/29/08 3,360 15 13 5. Chart 2.—Ammonia output and acidosis index, plotted from record of diabeticpatient (Table 1). It will be observed that there is a well-marked parallelism in the threecurves. The similarity in the curves of the acidosis index and thetotal acidosis accurately estimated in grams of oxybutyric acid is extra-ordinary. It is to be noted that while the parallelism of the three curves obtainedby different methods is quite evident, the values estimated from thepolariscopic readings are much too high, particularly in the largeramounts. This is entirely in harmony with the observations of MagnusLevy,^ who has pointed out that the polariscopic estimations of beta-oxybutyric acid have given exaggerated values. This may explain thevariations in the curves of Chart 1, where the polariscopic estimationsare relatively very high when the acidosis is high. For this reason, andon account of the fact that the acidosis index corresponds much betterwith the ammonia output (see Chart 2), I am inclined to


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