Archives of internal medicine . ^ gray red and opaquecolor of the marked hyperplasia as is classically seen in developing exoph-thalmic goiter. As true hyperplasia of the epithelial cells takes place,the follicles enlarge, and infoldings and plications of the lining epithe-. Fig. 19.—Carcinoma with lung metastases showing some differentiation,licles tend to grow out in tubules. Some stainable colloid. Fol- lium begin to appear in all encapsulated thyroids. These infoldings areless marked in non-encapsulated glands, as in the bony fish. The gland capsule and stroma hypertrophy parallel with the
Archives of internal medicine . ^ gray red and opaquecolor of the marked hyperplasia as is classically seen in developing exoph-thalmic goiter. As true hyperplasia of the epithelial cells takes place,the follicles enlarge, and infoldings and plications of the lining epithe-. Fig. 19.—Carcinoma with lung metastases showing some differentiation,licles tend to grow out in tubules. Some stainable colloid. Fol- lium begin to appear in all encapsulated thyroids. These infoldings areless marked in non-encapsulated glands, as in the bony fish. The gland capsule and stroma hypertrophy parallel with the epithelialproliferation and the increased blood-supply. In the early stages of hyper-plasia this hypertrophy is slight, while it may be unusually prominent inthe late stages, especially of exophthalmic goiter, as will be discussedmore fully under Atrophies. In the advanced stages of active hyperplasia and notably in exoph-thalmic goiter there are scattered throughout the stroma smaller or largergroups of lymphoid cells. These groups of lymphocytes are interpretedby some observers as evidence of a chronic inflammatory process, whileothers look on them as the local manifestation of the general lymphoid 520 TEE ARCHIVES OF IXTERXAL MEDlCiyE hyj)erplasia that is so co
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