Physiology and biochemistry in modern medicine . and others that stimulation of the superiorcervical ganglion, which has been known for many years to be fre-quently followed by glycosuria, has this effect only provided the posterior THE 1ITI ITAUY 1:V 771 lobe of the pituitary is intact. Even surgical manipulation f the pitui-tary may excite a hypersecretion of pituitrin, which would account forthe glycosuria often observed after experimental excision or partial destruction of the pituitary. A similar irritation may be set up in diseaseof the gland. The glycosuria which is usually observed aft
Physiology and biochemistry in modern medicine . and others that stimulation of the superiorcervical ganglion, which has been known for many years to be fre-quently followed by glycosuria, has this effect only provided the posterior THE 1ITI ITAUY 1:V 771 lobe of the pituitary is intact. Even surgical manipulation f the pitui-tary may excite a hypersecretion of pituitrin, which would account forthe glycosuria often observed after experimental excision or partial destruction of the pituitary. A similar irritation may be set up in diseaseof the gland. The glycosuria which is usually observed after partial hypophysectomysoon passes off, to be followed by a permanent condition of increasedtolerance for sugar, because now less pituitrin is being produced. It issaid that during the stage of increased tolerance diabetes can not be pro-duced even by excision of the pancreas. The glycosuria produced byirritation of the posterior lobe is accompanied by a marked polyuria (dia-betes insipidus), which may outlast the A. B. Fig. 199.—A, To show the appearance before the onset of acromegalic symptoms; B, The ap-pearance after seventeen years of the disease. (After Campbell Geddes.) Clinical Characteristics Because of their importance from a physiologic standpoint, we shallnow proceed to review briefly some of the more important facts that haveso far been brought to light by clinical observations. The pathologiccondition most frequently observed affecting the pituitary is an adenom-atous growth particularly located in the anterior lobe. Besides pro-ducing general symptoms of pressure, such as diminution of the visualfield and, perhaps, headache, a shadow can usually be observed when thepatient is examined by means of the x-rays. General symptoms, com-monly ascribed to a hypersecretion of the autacoid of the anterior lobe ofthe pituitary—hyperpituitarism—begin sooner or later to show them- 772 THK ENDOCRINE ORGANS, OR DUCTLESS GLANDS selves. These symptoms are alm
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