Archives of internal medicine . difference from the former examples lies in thefact that the allergen is not introduced directly in a maximum amount,but develops gradually during the incubation time. Therefore, the curve 416 TEE ARCHIVES OF INTERNAL MEDICINE above the line reaches its maximum on the tenth day; when its furthergrowth is checked by the appearance of the antibodies it decrease? digestion of the allergen again gives rise to general symptoms whichare noted as a feverish state of vaccinia. Two other experiments arenoted on the same figure. The one is revaccination in the
Archives of internal medicine . difference from the former examples lies in thefact that the allergen is not introduced directly in a maximum amount,but develops gradually during the incubation time. Therefore, the curve 416 TEE ARCHIVES OF INTERNAL MEDICINE above the line reaches its maximum on the tenth day; when its furthergrowth is checked by the appearance of the antibodies it decrease? digestion of the allergen again gives rise to general symptoms whichare noted as a feverish state of vaccinia. Two other experiments arenoted on the same figure. The one is revaccination in the usual minimal amount of allergen is put into the skin, producing a slightlocal reaction, while the general reaction does not reach the thresholdof clinical observation. But if we inject the lymph of vaccinia, therebyintroducing a large amount of allergen in the body, a greater amountof toxic body is formed, eliciting an intense local reaction and generalpymptoms, both disappearing rapidly.^ i Injection oftubercle baci. Limit Of death 1 Toxic w ffif m g ffi F@f :::^t B 1 *t -][ 1 1 .: 1 1 t T III Ij 1 U,^^P 1^4 i --^v m 1 Tr 1 i ti\:i di ti 1 Fig. 10.—Injection of large amount of tubercle bacilli. Figure 9 shows an accelerated reaction in vaccinia. The early reap-pearance of the antibody is analogous to the phenomenon shown in Figure5. The difference from a first vaccination (Fig. 8) is that the vacciniamicro-organisms have not had time to develop to any considerable extentduring the short time required for the production of the antibody. Thetoxic body formed is therefore too small in amount to give rise to anintense general reaction. It hardly reaches the threshold of clinical mani-festation, and the only phenomena seen are of a local nature. 2. Certain phenomena of lessened reactivity during the time of the first vac-cination are left out purposely, because the time is not yet ripe for the discussionof these complications. They are treated more explicitly in my boo
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