. Ciba Foundation Symposium on the Regulation of Cell Metabolism. Cell metabolism. Mechanism of Glycogen Synthesis in Muscle 191 an analogous experiment is presented using glucose-6-phosphate as the glucose donor for incorporation. Although here some incorpora- tion is maintained even with added kinase, its addition obviously depresses the incorporation. At the same time, as seen on the right- hand part of Fig. 5, it appears that with kinase added, glycogen Control Pho3phopylase kinase added. Time in minutes Fig. 4. Effect of phosphorylase kinase on the incorporation of glucose into glycogen.


. Ciba Foundation Symposium on the Regulation of Cell Metabolism. Cell metabolism. Mechanism of Glycogen Synthesis in Muscle 191 an analogous experiment is presented using glucose-6-phosphate as the glucose donor for incorporation. Although here some incorpora- tion is maintained even with added kinase, its addition obviously depresses the incorporation. At the same time, as seen on the right- hand part of Fig. 5, it appears that with kinase added, glycogen Control Pho3phopylase kinase added. Time in minutes Fig. 4. Effect of phosphorylase kinase on the incorporation of glucose into glycogen. The experiments were carried out in Warburg flasks as described by Robbins, Traut and Lipmann (1959). The homogenates were supplemented with kochsaft (0-2 ) and with crystalline phos- phorylase b (Fischer and Krebs, 1958). Phosphorylase kinase was prepared according to Krebs and Fischer (1956). Incorporation was measured as described previously (Robbins, Traut and Lipmann, 1959) and phosphorylase was assayed according to Cori and co-workers (1955). disappearance was accelerated. It may be noted that the induction period for incorporation with free glucose is absent with glucose phosphate. Apparently, conversion of glucose phosphate is more direct (cf. below). The results of this experiment forced us to consider the possibility that phosphorylase a may not be concerned physiologically with. Please note that these images are extracted from scanned page images that may have been digitally enhanced for readability - coloration and appearance of these illustrations may not perfectly resemble the original Ciba Foundation Symposium on the Regulation of Cell Metabolism (1958 : London, England); Wolstenholme, G. E. W. (Gordon Ethelbert Ward); O'Connor, Cecilia M. (Cecilia Mary), 1927-. Boston, Little, Brown


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