. Ciba Foundation conferences on istopes in biochemistry;. Radioactive tracers in biochemistry; Isotopes -- Physiological effect. Rate of Protein Synthesis in Man 195 The rate of clearance of urea from the urea pool in equation 1 is determined by the size of 'EJV. The half time, t^yg) is given by ^ti/2=In 2=0-693 (5) Since Eu/U is approximately 2, ti/2 is close to 1/3 day or eight hours. In this period half of the urea present in the urea pool will be excreted. o S z < UJ a: o o o -J Ol lu X. u. O z i= ABS JI _, * 50 100 TIME MINUTES 150 Fig. 2. Isotope concentration of the urea p
. Ciba Foundation conferences on istopes in biochemistry;. Radioactive tracers in biochemistry; Isotopes -- Physiological effect. Rate of Protein Synthesis in Man 195 The rate of clearance of urea from the urea pool in equation 1 is determined by the size of 'EJV. The half time, t^yg) is given by ^ti/2=In 2=0-693 (5) Since Eu/U is approximately 2, ti/2 is close to 1/3 day or eight hours. In this period half of the urea present in the urea pool will be excreted. o S z < UJ a: o o o -J Ol lu X. u. O z i= ABS JI _, * 50 100 TIME MINUTES 150 Fig. 2. Isotope concentration of the urea pool following intra- venous injection of ^^N urea. The same results can be obtained in determining the rate of excretion in the urine of the labelled urea. If A^ is the total urea ^^N excreted in the urine, then a plot of the logarithm jl—^1 vs. time yields a straight line (see Fig. 3). The slope of this line is equal to E^/U. of 1. Please note that these images are extracted from scanned page images that may have been digitally enhanced for readability - coloration and appearance of these illustrations may not perfectly resemble the original Ciba Foundation. Philadelphia, Blakiston
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