AMAarchives of neurology & psychiatry . gic characteristics as those recovered by Loewe and The cases which came to necropsy ran typical clinical courses andvaried from a fulminating case, with death eighteen hours after thefirst symptoms, to one of lethargic type which lasted eighteen monthswith remissions and relapses. 292 AKCnniiS OF SEUROLOGY AND ISYCIIIATKY Tlie brains in all these cases showed characteristic lesions ; that is,perivascular round cell infiltration and focalized areas of degenerati(niand round cell infiltration, most numerous in the pons and midbrainregion. In the
AMAarchives of neurology & psychiatry . gic characteristics as those recovered by Loewe and The cases which came to necropsy ran typical clinical courses andvaried from a fulminating case, with death eighteen hours after thefirst symptoms, to one of lethargic type which lasted eighteen monthswith remissions and relapses. 292 AKCnniiS OF SEUROLOGY AND ISYCIIIATKY Tlie brains in all these cases showed characteristic lesions ; that is,perivascular round cell infiltration and focalized areas of degenerati(niand round cell infiltration, most numerous in the pons and midbrainregion. In the two fulminating cases the lesions were definite but fewin number. This is of imixjrtance since, in the cases studied byMcintosh and Turnbull, no lesions were found. Some of the brainsfrom rabbits, which in the present study succumbed after inoculation,showed no lesions even though the virus was present, as was proved byculture and bv transmission to other rabbits. ^— »? rf . ^.A ,< -I ^- ^^ .-i* • <^ ** i. *«^ ..•^•v. Fig. 5.—Brain of a rabbit inoculated intracranially with virus which hadbeen passed through three other ral)bits. Necropsies were performed on seven cases of epidemic (through Mandler clay filters tested to hold back B. pro-digiosus) from five brains yielded positive animal inoculations andcultures. One brain filtrate yielded only positive cultures and one brainonly positive animal inoculation, but from these animals the minutefiltral)le organism was recovered. Positive results, including bothcultures and animal inoculation, were obtained in 100 per cent, of theseven brains studied. THALHIMER—EPIDEMIC E\ CEPHALITIS 293 The number of spinal fluids investigated was forty-five, securedfrom thirty-five cases. Positive cultures were obtained from spinalfluid from twenty-four cases, which is 70 per cent, of the cases and53 per cent, of the spinal fluids examined. Positive animal inoculationwas secured with spinal fluid from tw
Size: 897px × 2787px
Photo credit: © The Reading Room / Alamy / Afripics
License: Licensed
Model Released: No
Keywords: ., bookcentury1900, bookdecade1910, bookpublisherchica, bookyear1919
