Diffuse large B-cell lymphoma, light micrograph. Diffuse large B-cell lymphoma is the most common type of lymphoma and accounts for about 35% of all c
Diffuse large B-cell lymphoma, light micrograph. Diffuse large B-cell lymphoma is the most common type of lymphoma and accounts for about 35% of all cases of non-Hodgkin lymphoma. It is an aggressive malignancy and presents with rapidly enlarging lymph nodes or tumor masses at extranodal sites. There is diffuse proliferation of large to medium-sized lymphoid cells which can be classified into centroblasts and immunoblasts. Some cases have markedly pleomorphic anaplastic cells. This is a photomicrograph of diffuse large B-cell lymphoma of stomach in a gastric biopsy from a patient who presented with gastritis. The lymphoma cells diffusely infiltrate in between the gastric glands causing wide separation and disrupting the native architecture. They have round, oval, or irregular nuclei, multiple punctate nucleoli, and scant cytoplasm.
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Photo credit: © WEBPATHOLOGY/SCIENCE PHOTO LIBRARY / Alamy / Afripics
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