Nervous and mental diseases . e,1 however, found degeneration of posterior root-fibers, and pos-terior root-zones. The cranial nerves are generally spared in the spinalvariety, but the hypoglossus and optic nerves have been found cerebellar form, in the few cases on record, has presented atrophyof the cerebellum, as in Frasers case, in one of Nonnes, in Switalskis,and in Holmes This is absent in Browns cases, but the cerebellartracts in the cord were involved. This cerebellar atrophy is said not to besclerotic. The gray substance is abnormally thin, Purkinjes cells are fewi
Nervous and mental diseases . e,1 however, found degeneration of posterior root-fibers, and pos-terior root-zones. The cranial nerves are generally spared in the spinalvariety, but the hypoglossus and optic nerves have been found cerebellar form, in the few cases on record, has presented atrophyof the cerebellum, as in Frasers case, in one of Nonnes, in Switalskis,and in Holmes This is absent in Browns cases, but the cerebellartracts in the cord were involved. This cerebellar atrophy is said not to besclerotic. The gray substance is abnormally thin, Purkinjes cells are fewin number and undersized, the white matter is less voluminous than usual,and the weight of the organ is reduced a third or a half. The cord in thesecases of Maries type is undersized, but shows no sclerotic appears to be a pure genetic poverty of fibers, or else they havedisappeared, leaving no trace. In Browns cases, as reported by Meyerand later by Barker,3 there was degeneration in the dorsolateral cere-. m^^ Fig. 201.—Dorsal cord-section in Friedreichs disease, showing distribution and relative intensity of sclerotic changes (.Marie). bellar tract and degeneration in the gray and white matter of the cord,medulla, and cerebellum. Optic atrophy is not infrequent. Symptoms.—The motor symptoms are the most prominent. Theycommence with clumsiness, especially in walking. The child stumblesover every trifle and becomes more and more unsteady on its the gait is staggering and drunken in its uncertainty. Ataxiamarks every movement and position, but there is no rigidity even .inthe cases presenting increased reflexes. All movements are clearlyintentional, though clumsily executed, and have for their purpose tomaintain the insecure equilibrium. In standing the body is constantlyswaying, and shuffling steps in various directions are frequently takento maintain the balance. With closed eyes the difficulties of the stationand gait are not notably increas
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