. Journal of radiology . odied of an osteosarcoma of the legand spine , had had her hospital statis-tics taken even seven generations with-out error, there would have been noappearance of tumor. Nevertheless, bytracing far enough back, we find theancestor with malignant disease. Thischart shows with what certainty thetendency to neoplasms can be manipu-lated and controlled. Through genera-tion after generation it was carriedalong by heterozygous individuals, cer-tain to appear when the right matingswere made. Chart 15Chart 15 shows Line C of thisbranch of Strain 1 64 continued throughseven gen
. Journal of radiology . odied of an osteosarcoma of the legand spine , had had her hospital statis-tics taken even seven generations with-out error, there would have been noappearance of tumor. Nevertheless, bytracing far enough back, we find theancestor with malignant disease. Thischart shows with what certainty thetendency to neoplasms can be manipu-lated and controlled. Through genera-tion after generation it was carriedalong by heterozygous individuals, cer-tain to appear when the right matingswere made. Chart 15Chart 15 shows Line C of thisbranch of Strain 1 64 continued throughseven generations. Here, by matingtumorous female 10537 with provednon-tumorous male 8247, no tumor oc-curred in the next generation. But bythe selection of two heterozygotes ofgeneration 4, carcinoma appeared inthe succeeding generation (generation5) in female 12779 with a squamouscell carcinoma of the neck and pseudo- > Or !l 105,7 j|8521 , i ::: OF STRAIN 164-BR .... , I CHA.*.T 1* OF IfaT • BK. lH. 461 INHERIT ABILITY OF SPONTANEOUS CANCER—SLYE leukemia. Again, by the mating ofthis female with heterozygous male1 6667, note how both pseudoleukemiaoccurred in the next generation, male14631, and also squamous cell carci-noma of the neck, which at death hadextended anteriorly and obliterated theface, male 14583. Female 18413,daughter of male 14583, showed thecarcinoma of the mammary gland ofher grandmother four generations backand the sarcoma of her grandfatherfive generations back. When a giventype or location of neoplasm is bred in,it can be manipulated with absoluteaccuracy by the type of selective breed-ing used. It can be made to hold offfor any number of generations desired,or to appear in the next generation, asin the case of male 14583 with asquamous cell carcinoma of the neckin generation 6, following female12779 with a squamous cell carcinomaof the neck in generation 5; or male14631 with pseudoleukemia in genera-tion 6 following female 12779 with
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