. Contributions. Biology. 328 Philip H. Mitchell and George Smith. intravenously to a dog of 20 kilos, caused in a few minutes un- mistakable intestinal rumblings. In all the dogs used defecation occurred several times, even though stools had previously been passed at the time of etherizing. In the course of an hour, after three or more injections of small quantities, fluid or semi-fluid feces were. T ji n ^jinnAnA/uirinj^ Figure 3. — The effect on the heart of cumulative action of the alkaloid. Upper trac- ing shows carotid pressure, lower one respiration
. Contributions. Biology. 328 Philip H. Mitchell and George Smith. intravenously to a dog of 20 kilos, caused in a few minutes un- mistakable intestinal rumblings. In all the dogs used defecation occurred several times, even though stools had previously been passed at the time of etherizing. In the course of an hour, after three or more injections of small quantities, fluid or semi-fluid feces were. T ji n ^jinnAnA/uirinj^ Figure 3. — The effect on the heart of cumulative action of the alkaloid. Upper trac- ing shows carotid pressure, lower one respiration. Time = sec. At A gm. of the alkaloid in 5 of saline was injected. The vagi were intact. By means of three previous injections, gm. of the substance had been given. observed in each case. Micturition also took place in many of the dogs during the experiment. This involuntary evacuation of in- testines and bladder in anaesthetized dogs was plainly the result of the action of the alkaloid, because effects followed quickly after in- jection and in the case of defecation were proportional to the amount given. Such results confirm our observations with guinea-pigs. The influence of the substance on the vomiting mechanism of dogs was not tested, as in guinea-pigs, because no injections were made with- out previous anaesthesia. Several of the dogs while still anaesthetized were killed by intra- venous injection of a fatal dose. In each case the heart beat became very irregular and soon stopped. Invariably the heart failed before respiration. At the moment respiration ceased, however, the dog passed into a death struggle exhibiting tetanic spasms of the entire. Please note that these images are extracted from scanned page images that may have been digitally enhanced for readability - coloration and appearance of these illustrations may not perfectly resemble the original Brown University. Biological Laboratory. Providence, R. I
Size: 3352px × 745px
Photo credit: © The Book Worm / Alamy / Afripics
License: Licensed
Model Released: No
Keywords: ., bookcentury1800, bookdecade1890, bookpublishe, booksubjectbiology
