Medical bulletin . * In the experiments thus marked the heart did not stop. t This animal had received the preceding dose of 30 mgm. x kgm. of apothesin55 minutes earlier. J In the experiments marked cardiac massage was employed. § In these two experiments the cats were identified as having received ouabain,unknown to the experimenter—see text. 1[ This animal had been given the dose of 40 mgm. x kgm. of nirvanin, recordedabove, one hour earlier. 482 GARY EGGLESTON AND ROBERT A. HATCHER. PHARMACOLOGY OF LOCAL ANESTHETICS 483 Table 7 gives the important details of each of this series oftwe
Medical bulletin . * In the experiments thus marked the heart did not stop. t This animal had received the preceding dose of 30 mgm. x kgm. of apothesin55 minutes earlier. J In the experiments marked cardiac massage was employed. § In these two experiments the cats were identified as having received ouabain,unknown to the experimenter—see text. 1[ This animal had been given the dose of 40 mgm. x kgm. of nirvanin, recordedabove, one hour earlier. 482 GARY EGGLESTON AND ROBERT A. HATCHER. PHARMACOLOGY OF LOCAL ANESTHETICS 483 Table 7 gives the important details of each of this series oftwenty-three experiments and shows that the administration ofa dose of mgm. x kgm. or over of ouabain effectively pro-tects the heart from permanent stoppage by doses of the localanesthetics ranging from 117 to 175 per cent of the average the twenty-one experiments in which mgm. x kgm. ormore of ouabain was given, death followed tlic administration ofthe local anesthetic in only five. Of these five deaths, one fol-lowed the administration of twice the fatal dose of apothesin toa cat which, fifty-five minutes before, had been given a dose ofthe same drug 50 per cent greater than the average fatal andhad recovered. A second death followed the administration of148 per cent of the fatal dose of stovain to a cat which had sur-vived 125 per cent of the average fatal dose of nirvanin given anhour earUer. Excluding these two, death followed the adminis-tration of these large d
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