. The thyroid gland in health and disease. orption of a numberof the new-formed elements occurs, and iodine is again storedin the colloid (figs. 17, 18).i The gland reverts to a statewhich may approach very nearly to normal, but it shows ^ In goitre produced experimentally in rats by means of faecal material or bycultures from fseces, the contintious administration of these toxic materials does notpermit the gland to revert to the colloid state. Under the conditions of the experi-ment they are allowed no period of rest, consequently no colloid accumulates in thehyperplastic organ.—R. McC. 68 P
. The thyroid gland in health and disease. orption of a numberof the new-formed elements occurs, and iodine is again storedin the colloid (figs. 17, 18).i The gland reverts to a statewhich may approach very nearly to normal, but it shows ^ In goitre produced experimentally in rats by means of faecal material or bycultures from fseces, the contintious administration of these toxic materials does notpermit the gland to revert to the colloid state. Under the conditions of the experi-ment they are allowed no period of rest, consequently no colloid accumulates in thehyperplastic organ.—R. McC. 68 PATHOLOGY the scars of its encounter with the exciting toxins in theseways :— It is usually increased in size to a greater or lesser capsule is thicker ; its stroma more vesicles are more irregular in shape and size, and mayshow evidences of the previous hyperplasia in the formof sprig-like jDrojections into the interior of the acini,or areas of hyiDcrplasia may be found in the intervesi-cular tissue (fig. 18).. Fig. 17.—Section of normal thyroid gland, in colloid or resting state, fromhuman subject. (Reproduced by the courtesy of Dr. David Marine, of Cleveland).X 50. Its artery walls are thickened by a process of obliterating endarteritis, or they may even show veins are lessened in their calibre and the walls of itslymph trunks are appearances will vary with the duration of the hyper-plastic stage, and the length of time since reversion to the colloidstage has taken place (fig. 18). Thus the gland may appearmore colloid in type and less hyperplastic or vice versa, accordingto the stage of the process at which it is observed. This ])rocess of reversion to the colloid state, first accuratelydescribed by Marine and Lenhart, represents the second stage in ENDEMIC GOITRE 69 the production of simple as opposed to exophthalmic onset in the case of endemic goitre is determined by the factthat goitrigenous infl
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