. Ciba Foundation Symposium on the Regulation of Cell Metabolism. Cell metabolism. 276 Discussion conditions, despite the fact that some kind of steady state is finally reached, which might be equal or different for both conditions. Lynen: I agree that if you study different conditions you will have different effects. I would emphasize that the control of fermentation by lack of ADP seems to me impossible if ATP is available at the same time. The phosphorylation of hexose by ATP would continuously regenerate ADP. Hess: This is a question of the ratio between dephosphorylation and phosphorylati
. Ciba Foundation Symposium on the Regulation of Cell Metabolism. Cell metabolism. 276 Discussion conditions, despite the fact that some kind of steady state is finally reached, which might be equal or different for both conditions. Lynen: I agree that if you study different conditions you will have different effects. I would emphasize that the control of fermentation by lack of ADP seems to me impossible if ATP is available at the same time. The phosphorylation of hexose by ATP would continuously regenerate ADP. Hess: This is a question of the ratio between dephosphorylation and phosphorylation. In non-respiring ascites cells the ATP/ADP ratio is 1/1 and in respiring cells it is about 7/1 or even 10/1. Lynen: I do not agree on this point. According to our analysis, and as far as I know, Prof. Holzer has had similar results, the ATP/ADP ratio does not change when you switch from nitrogen to oxygen. How- ever, these determinations did not differentiate between cytoplasmic and mitochondrial ATP; the eventual transport of ATP from cytoplasm to mitochondria could not be detected by our method. 4. Please note that these images are extracted from scanned page images that may have been digitally enhanced for readability - coloration and appearance of these illustrations may not perfectly resemble the original Ciba Foundation Symposium on the Regulation of Cell Metabolism (1958 : London, England); Wolstenholme, G. E. W. (Gordon Ethelbert Ward); O'Connor, Cecilia M. (Cecilia Mary), 1927-. Boston, Little, Brown
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